A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges

Open Access

Peer-reviewed

Research Article

Sander Land ,

* E-mail: sander.land@kcl.ac.uk

Affiliation Department of Biomedical Engineering, King’s College London, United Kingdom
⨯
Steven A. Niederer

Affiliation Department of Biomedical Engineering, King’s College London, United Kingdom
⨯

About the Authors

Sander Land

* E-mail: sander.land@kcl.ac.uk

Affiliation Department of Biomedical Engineering, King’s College London, United Kingdom

Steven A. Niederer

Affiliation Department of Biomedical Engineering, King’s College London, United Kingdom

The authors have declared that no competing interests exist.

Conceived and designed the experiments: SL SAN. Performed the experiments: SL. Analyzed the data: SL. Wrote the paper: SL SAN.

Tropomyosin
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Myosins
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Troponin
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Deformation
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Free energy
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Mechanical tension
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Biophysics
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Muscle functions
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