Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms

Greet De Baets; Loic Van Doorn; Frederic Rousseau; Joost Schymkowitz

doi:10.1371/journal.pcbi.1004374

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Open Access

Peer-reviewed

Research Article

Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms

Greet De Baets,

Affiliations VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Switch Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium
⨯
Loic Van Doorn,

Affiliations VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Switch Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium
⨯
Frederic Rousseau ,

* E-mail: Frederic.Rousseau@switch.vib-kuleuven.be (FR); Joost.Schymkowitz@switch.vib-kuleuven.be (JS)

Affiliations VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Switch Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium
⨯
Joost Schymkowitz

* E-mail: Frederic.Rousseau@switch.vib-kuleuven.be (FR); Joost.Schymkowitz@switch.vib-kuleuven.be (JS)

Affiliations VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Switch Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium
⨯

Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms

Greet De Baets,
Loic Van Doorn,
Frederic Rousseau,
Joost Schymkowitz

Published: September 4, 2015
https://doi.org/10.1371/journal.pcbi.1004374

About the Authors

Greet De Baets

Affiliations VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Switch Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium

Loic Van Doorn

Frederic Rousseau

* E-mail: Frederic.Rousseau@switch.vib-kuleuven.be (FR); Joost.Schymkowitz@switch.vib-kuleuven.be (JS)

Joost Schymkowitz

* E-mail: Frederic.Rousseau@switch.vib-kuleuven.be (FR); Joost.Schymkowitz@switch.vib-kuleuven.be (JS)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FR JS. Performed the experiments: GDB LVD. Analyzed the data: GDB LVD FR JS. Contributed reagents/materials/analysis tools: GDB FR JS. Wrote the paper: GDB FR JS.

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Protein domains
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Mutation databases
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Protein aggregation
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Globular proteins
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Cancers and neoplasms
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Pathogens
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Protein structure
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Intrinsically disordered proteins
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