About the Authors

Rong Shen

Affiliation Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, United States of America

Wei Han

Affiliation Beckman Institute, University of Illinois at Urbana–Champaign, Urbana, Illinois, United States of America

Giacomo Fiorin

Affiliation Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

Shahidul M. Islam

Affiliation Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, United States of America

Klaus Schulten

Affiliation Beckman Institute, University of Illinois at Urbana–Champaign, Urbana, Illinois, United States of America

Benoît Roux

roux@uchicago.edu

Affiliation Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS WH GF SMI KS BR. Performed the experiments: RS WH GF SMI. Analyzed the data: RS WH GF SMI. Contributed reagents/materials/analysis tools: RS WH GF SMI. Wrote the paper: RS WH GF SMI KS BR.