Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition

Thomas Hoffmann; Angela M. Krackhardt; Iris Antes

doi:10.1371/journal.pcbi.1004244

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Open Access

Peer-reviewed

Research Article

Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition

Thomas Hoffmann,

Affiliation Department of Biosciences and Center for Integrated Protein Science Munich,Technische Universität München, Freising-Weihenstephan, Germany
⨯
Angela M. Krackhardt,

Affiliations Medizinische Klinik III, Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Technische Universität München, Munich, Germany, Clinical Cooperation Group, Antigen specific T cell therapy, Helmholtz Zentrum München (GmbH), German Center for Environmental Health, Munich, Germany, German Cancer Consortium (DKTK), Munich, Germany
⨯
Iris Antes

* E-mail: antes@tum.de

Affiliation Department of Biosciences and Center for Integrated Protein Science Munich,Technische Universität München, Freising-Weihenstephan, Germany
⨯

Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition

Thomas Hoffmann,
Angela M. Krackhardt,
Iris Antes

Published: July 17, 2015
https://doi.org/10.1371/journal.pcbi.1004244

About the Authors

Thomas Hoffmann

Affiliation Department of Biosciences and Center for Integrated Protein Science Munich,Technische Universität München, Freising-Weihenstephan, Germany

Angela M. Krackhardt

Affiliations Medizinische Klinik III, Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Technische Universität München, Munich, Germany, Clinical Cooperation Group, Antigen specific T cell therapy, Helmholtz Zentrum München (GmbH), German Center for Environmental Health, Munich, Germany, German Cancer Consortium (DKTK), Munich, Germany

Iris Antes

* E-mail: antes@tum.de

Affiliation Department of Biosciences and Center for Integrated Protein Science Munich,Technische Universität München, Freising-Weihenstephan, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TH AMK IA. Performed the experiments: TH. Analyzed the data: TH IA. Contributed reagents/materials/analysis tools: TH IA. Wrote the paper: TH AMK IA.

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T cell receptors
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Major histocompatibility complex
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Crystal structure
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Hydrogen bonding
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T cells
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TCR signaling cascade
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Geometry
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Pattern recognition receptors
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