About the Authors

Hanae Shimo

Current address: Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Affiliations Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Osaka, Japan, Department of Biochemistry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

Satya Nanda Vel Arjunan

Affiliation Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Osaka, Japan

Hiroaki Machiyama

Affiliations Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Osaka, Japan, Immunology Frontier Research Center, Osaka University, Osaka, Japan

Taiko Nishino

Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

Makoto Suematsu

Affiliations Department of Biochemistry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan, Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

Hideaki Fujita

Affiliations Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Osaka, Japan, Immunology Frontier Research Center, Osaka University, Osaka, Japan

Masaru Tomita

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Department of Environment and Information Studies, Keio University, Fujisawa, Kanagawa, Japan

Koichi Takahashi

ktakahashi@riken.jp

Affiliations Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Osaka, Japan, Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HS SNVA TN KT. Performed the experiments: HS HM. Analyzed the data: HS TN. Contributed reagents/materials/analysis tools: SNVA HM HF MT KT. Wrote the paper: HS SNVA TN MS KT. Supervised overall for this research: SNVA MS HF MT KT.