The Serotype Distribution among Healthy Carriers before Vaccination Is Essential for Predicting the Impact of Pneumococcal Conjugate Vaccine on Invasive Disease

Stefan Flasche; Olivier Le Polain de Waroux; Katherine L. O’Brien; W. John Edmunds

doi:10.1371/journal.pcbi.1004173

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Open Access

Peer-reviewed

Research Article

The Serotype Distribution among Healthy Carriers before Vaccination Is Essential for Predicting the Impact of Pneumococcal Conjugate Vaccine on Invasive Disease

Stefan Flasche ,

* E-mail: Stefan.Flasche@lshtm.ac.uk

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Olivier Le Polain de Waroux,

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Katherine L. O’Brien,

Affiliation International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
W. John Edmunds

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

The Serotype Distribution among Healthy Carriers before Vaccination Is Essential for Predicting the Impact of Pneumococcal Conjugate Vaccine on Invasive Disease

Stefan Flasche,
Olivier Le Polain de Waroux,
Katherine L. O’Brien,
W. John Edmunds

Published: April 16, 2015
https://doi.org/10.1371/journal.pcbi.1004173

About the Authors

Stefan Flasche

* E-mail: Stefan.Flasche@lshtm.ac.uk

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom

Olivier Le Polain de Waroux

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom

Katherine L. O’Brien

Affiliation International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

W. John Edmunds

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SF WJE. Performed the experiments: SF OLPdW. Analyzed the data: SF OLPdW KLO WJE. Wrote the paper: SF OLPdW KLO WJE.

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Vaccination and immunization
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Vaccines
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Conjugate vaccines
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Epidemiology
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Disease surveillance
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Forecasting
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Metaanalysis
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Pneumococcus
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