Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution

Christiaan H. van Dorp; Michiel van Boven; Rob J. de Boer

doi:10.1371/journal.pcbi.1003899

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Open Access

Peer-reviewed

Research Article

Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution

Christiaan H. van Dorp ,

* E-mail: C.H.vanDorp@uu.nl

Affiliations Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Michiel van Boven,

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Rob J. de Boer

Affiliation Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands
⨯

Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution

Christiaan H. van Dorp,
Michiel van Boven,
Rob J. de Boer

Published: December 18, 2014
https://doi.org/10.1371/journal.pcbi.1003899

About the Authors

Christiaan H. van Dorp

* E-mail: C.H.vanDorp@uu.nl

Affiliations Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Michiel van Boven

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Rob J. de Boer

Affiliation Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHvD MvB RJdB. Performed the experiments: CHvD. Analyzed the data: CHvD MvB RJdB. Wrote the paper: CHvD MvB RJdB.

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HIV-1
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Deletion mutation
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Microbial mutation
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Immune response
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Viral evolution
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Evolutionary immunology
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Evolutionary adaptation
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Heredity
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