About the Authors

Matthew N. Benedict

Affiliation Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Michael B. Mundy

Affiliation Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America

Christopher S. Henry

Affiliation Mathematics and Computer Science Division, Argonne National Laboratory, Lemont, Illinois, United States of America

Nicholas Chia

chia.nicholas@mayo.edu (NC); nprice@systemsbiology.org (NDP)

Affiliations Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Physiology and Bioengineering, Mayo Clinic, Rochester, Minnesota, United States of America

Nathan D. Price

chia.nicholas@mayo.edu (NC); nprice@systemsbiology.org (NDP)

Affiliations Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Institute for Systems Biology, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MNB MBM NC CSH NDP. Performed the experiments: MNB MBM. Analyzed the data: MNB MBM. Contributed reagents/materials/analysis tools: MNB MBM NC CSH. Wrote the paper: MNB MBM NC CSH NDP.