About the Authors

James Dunbar

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Bernhard Knapp

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Angelika Fuchs

Affiliation F. Hoffmann-La Roche Ltd, Pharma Research and Early Development, Informatics, Penzberg, Germany

Jiye Shi

Affiliation Informatics, UCB Pharma, Slough, United Kingdom

Charlotte M. Deane

deane@stats.ox.ac.uk

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Competing Interests

JS is an employee of UCB Pharma, AF is an employee of F. Hoffmann-La Roche, JD is partially funded by UCB Pharma and F. Hoffmann-La Roche. This does not alter our adherence to the PLOS policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JD AF JS CMD. Performed the experiments: JD. Analyzed the data: JD. Contributed reagents/materials/analysis tools: JD BK. Contributed to the writing of the manuscript: JD BK AF JS CMD.