About the Authors

Marnix H. Medema

marnixmedema@gmail.com

Current address: Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen, Germany

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands

Yared Paalvast

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands

Don D. Nguyen

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

Alexey Melnik

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

Pieter C. Dorrestein

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

Eriko Takano

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Rainer Breitling

Affiliations Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: MHM. Contributed to the writing of the manuscript: MHM. First conceived of the study: MHM PCD. Designed the algorithm: MHM RB. Wrote early prototype of the software: YP. Wrote the final software: MHM. Tested and validated the software: MHM DDN AM. Provided feedback on manuscript and figures content: YP DDN AM PCD ET RB.