Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS

Sharlee Climer; Alan R. Templeton; Weixiong Zhang

doi:10.1371/journal.pcbi.1003766

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Open Access

Peer-reviewed

Research Article

Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS

Sharlee Climer ,

* E-mail: climer@wustl.edu (SC); weixiong.zhang@wustl.edu (WZ)

Affiliation Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America
⨯
Alan R. Templeton,

Affiliations Department of Biology, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute of Evolution, and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel
⨯
Weixiong Zhang

* E-mail: climer@wustl.edu (SC); weixiong.zhang@wustl.edu (WZ)

Affiliations Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China
⨯

Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS

Sharlee Climer,
Alan R. Templeton,
Weixiong Zhang

Published: September 18, 2014
https://doi.org/10.1371/journal.pcbi.1003766

About the Authors

Sharlee Climer

* E-mail: climer@wustl.edu (SC); weixiong.zhang@wustl.edu (WZ)

Affiliation Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America

Alan R. Templeton

Affiliations Department of Biology, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute of Evolution, and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel

Weixiong Zhang

* E-mail: climer@wustl.edu (SC); weixiong.zhang@wustl.edu (WZ)

Affiliations Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SC ART WZ. Performed the experiments: SC. Analyzed the data: SC ART WZ. Contributed reagents/materials/analysis tools: SC ART WZ. Wrote the paper: SC ART WZ. Algorithm and software development: SC.

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Single nucleotide polymorphisms
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Psoriasis
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Genome-wide association studies
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Network analysis
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Genetics of disease
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Permutation
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Variant genotypes
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Medical risk factors
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