Dendritic Nonlinearities Reduce Network Size Requirements and Mediate ON and OFF States of Persistent Activity in a PFC Microcircuit Model

Athanasia Papoutsi; Kyriaki Sidiropoulou; Panayiota Poirazi

doi:10.1371/journal.pcbi.1003764

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Peer-reviewed

Research Article

Dendritic Nonlinearities Reduce Network Size Requirements and Mediate ON and OFF States of Persistent Activity in a PFC Microcircuit Model

Athanasia Papoutsi,

Affiliations Institute of Molecular Biology and Biotechnology (IMBB) – Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece, Department of Biology, University of Crete, Heraklion, Crete, Greece
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Kyriaki Sidiropoulou,

Affiliations Institute of Molecular Biology and Biotechnology (IMBB) – Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece, Department of Biology, University of Crete, Heraklion, Crete, Greece
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Panayiota Poirazi

* E-mail: poirazi@imbb.forth.gr

Affiliation Institute of Molecular Biology and Biotechnology (IMBB) – Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece
⨯

Dendritic Nonlinearities Reduce Network Size Requirements and Mediate ON and OFF States of Persistent Activity in a PFC Microcircuit Model

Athanasia Papoutsi,
Kyriaki Sidiropoulou,
Panayiota Poirazi

Published: July 31, 2014
https://doi.org/10.1371/journal.pcbi.1003764

About the Authors

Athanasia Papoutsi

Affiliations Institute of Molecular Biology and Biotechnology (IMBB) – Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece, Department of Biology, University of Crete, Heraklion, Crete, Greece

Kyriaki Sidiropoulou

Panayiota Poirazi

* E-mail: poirazi@imbb.forth.gr

Affiliation Institute of Molecular Biology and Biotechnology (IMBB) – Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PP AP KS. Performed the experiments: AP. Analyzed the data: AP. Contributed reagents/materials/analysis tools: AP PP. Wrote the paper: PP AP KS.

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Neuronal dendrites
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Neurons
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Action potentials
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Microcircuits
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Prefrontal cortex
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Neural networks
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Interneurons
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Depolarization
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