Prediction and Prioritization of Rare Oncogenic Mutations in the Cancer Kinome Using Novel Features and Multiple Classifiers

ManChon U; Eric Talevich; Samiksha Katiyar; Khaled Rasheed; Natarajan Kannan

doi:10.1371/journal.pcbi.1003545

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Open Access

Peer-reviewed

Research Article

Prediction and Prioritization of Rare Oncogenic Mutations in the Cancer Kinome Using Novel Features and Multiple Classifiers

ManChon U ,

Contributed equally to this work with: ManChon U, Eric Talevich

Affiliation Department of Computer Science, University of Georgia, Athens, Georgia, United States of America
⨯
Eric Talevich ,

Contributed equally to this work with: ManChon U, Eric Talevich

Affiliation Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America
⨯
Samiksha Katiyar,

Affiliation Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Khaled Rasheed,

Affiliation Department of Computer Science, University of Georgia, Athens, Georgia, United States of America
⨯
Natarajan Kannan

* E-mail: kannan@bmb.uga.edu

Affiliations Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America
⨯

Prediction and Prioritization of Rare Oncogenic Mutations in the Cancer Kinome Using Novel Features and Multiple Classifiers

ManChon U,
Eric Talevich,
Samiksha Katiyar,
Khaled Rasheed,
Natarajan Kannan

Published: April 17, 2014
https://doi.org/10.1371/journal.pcbi.1003545

About the Authors

ManChon U

Contributed equally to this work with: ManChon U, Eric Talevich

Affiliation Department of Computer Science, University of Georgia, Athens, Georgia, United States of America

Eric Talevich

Contributed equally to this work with: ManChon U, Eric Talevich

Affiliation Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

Samiksha Katiyar

Affiliation Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America

Khaled Rasheed

Affiliation Department of Computer Science, University of Georgia, Athens, Georgia, United States of America

Natarajan Kannan

* E-mail: kannan@bmb.uga.edu

Affiliations Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MCU ET SK KR NK. Performed the experiments: MCU ET SK. Analyzed the data: MCU ET SK KR NK. Wrote the paper: MCU ET SK KR NK.

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Point mutation
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Protein kinases
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Cancers and neoplasms
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Lung and intrathoracic tumors
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Machine learning
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Mutation databases
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Skin tumors
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Mutation
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