Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane

Navneet Bung; Meenakshi Pradhan; Harini Srinivasan; Gopalakrishnan Bulusu

doi:10.1371/journal.pcbi.1003484

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Open Access

Peer-reviewed

Research Article

Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane

Navneet Bung ,

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India
⨯
Meenakshi Pradhan ,

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India
⨯
Harini Srinivasan ,

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India
⨯
Gopalakrishnan Bulusu

* E-mail: g.bulusu@tcs.com

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India
⨯

Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane

Navneet Bung,
Meenakshi Pradhan,
Harini Srinivasan,
Gopalakrishnan Bulusu

Published: March 6, 2014
https://doi.org/10.1371/journal.pcbi.1003484

About the Authors

Navneet Bung

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

Meenakshi Pradhan

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

Harini Srinivasan

Contributed equally to this work with: Navneet Bung, Meenakshi Pradhan, Harini Srinivasan

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

Gopalakrishnan Bulusu

* E-mail: g.bulusu@tcs.com

Affiliation TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NB MP HS GB. Performed the experiments: NB MP HS. Analyzed the data: NB MP HS GB. Wrote the paper: NB MP HS GB.

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Biochemical cofactors
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Biochemical simulations
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Molecular dynamics
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Protein structure
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Crystal structure
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