Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection

Iren Bains; Hisse M. van Santen; Benedict Seddon; Andrew J. Yates

doi:10.1371/journal.pcbi.1003102

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Open Access

Peer-reviewed

Research Article

Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection

Iren Bains,

Affiliations Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom, Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America
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Hisse M. van Santen,

Affiliation Centro Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma de Madrid, Madrid, Spain
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Benedict Seddon,

Affiliation Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
⨯
Andrew J. Yates

* E-mail: andrew.yates@einstein.yu.edu

Affiliations Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America
⨯

Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection

Iren Bains,
Hisse M. van Santen,
Benedict Seddon,
Andrew J. Yates

Published: July 25, 2013
https://doi.org/10.1371/journal.pcbi.1003102

About the Authors

Iren Bains

Affiliations Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom, Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America

Hisse M. van Santen

Affiliation Centro Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma de Madrid, Madrid, Spain

Benedict Seddon

Affiliation Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

Andrew J. Yates

* E-mail: andrew.yates@einstein.yu.edu

Affiliations Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the study: IB AJY. Contributed data: HMvS. Performed analysis and modelling of data: IB AJY. Wrote the paper: IB HMvS BS AJY.

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TCR signaling cascade
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Thymocytes
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T cells
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Signal peptides
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Developmental signaling
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T cell receptors
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Thymus
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Regulatory T cells
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