A Universal Mechanism Ties Genotype to Phenotype in Trinucleotide Diseases

Shai Kaplan; Shalev Itzkovitz; Ehud Shapiro

doi:10.1371/journal.pcbi.0030235

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Open Access

Peer-reviewed

Research Article

A Universal Mechanism Ties Genotype to Phenotype in Trinucleotide Diseases

Shai Kaplan,

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Shalev Itzkovitz,

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel
⨯
Ehud Shapiro

*To whom correspondence should be addressed. E-mail: ehud.shapiro@weizmann.ac.il

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel
⨯

A Universal Mechanism Ties Genotype to Phenotype in Trinucleotide Diseases

Shai Kaplan,
Shalev Itzkovitz,
Ehud Shapiro

Published: November 23, 2007
https://doi.org/10.1371/journal.pcbi.0030235

About the Authors

Shai Kaplan

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Shalev Itzkovitz

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

Ehud Shapiro

*To whom correspondence should be addressed. E-mail: ehud.shapiro@weizmann.ac.il

Affiliations Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

Competing Interests

Weizmann Institute of Science may file a patent based on this work.

Author Contributions

SK and ES conceived and designed the experiments and wrote the paper. All authors analyzed the data and contributed reagents/materials/analysis tools.

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Alleles
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Cytopathology
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Homozygosity
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Trinucleotide repeats
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Mouse models
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Huntington disease
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Animal models of disease
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Somatic mutation
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