04/03/2026
Education
As data generation continues to accelerate, the life science and health communities are facing a growing need to master core bioinformatics skills. These communities encompass a diverse range of profiles from university undergraduates to professionals in research and medical institutions, eager to learn new analysis techniques.
Image credit: Kimberly Farmer
Current Issue February 2026
04/03/2026
research article
Multiple transmission pathways exist at the tick-host interface, including direct host-to-tick transmission, indirect cofeeding transmission between ticks, and pre-existing infection acquired vertically or during earlier feeding. Conventional approaches often assume simpler, more direct transmission dynamics, which hampers efforts to understand the transmission dynamics.
Image credit: Eric Karits
03/27/2026
research article
Recent observations have revealed that stable microbial communities contain a high number of species that cannot coexist in pairs, providing new empirical elements to explore this question from a fresh perspective. Using species-rich models of ecological communities with pairwise interactions alone, the authors show that emergent coexistence arises naturally in an extent that is consistent with empirical observations.
Image credit: Matthew Schwartz
03/16/2026
research article
Image credit: Stansfield et al
03/12/2026
resaerch article
Biotic interactions, crucial for understanding the ecology and evolution of species, are often conceptualized as ecological networks. However, the complexity of real ecosystems poses challenges for empirical inference, and theoretical interaction models, while informative, frequently fail to undergo empirical validation.
Image credit: Brun-Usan et al
03/12/2026
research article
The authors present AE-Trans, an interpretable dual-channel Transformer framework that integrates unpaired transcriptomic and epigenomic data to enhance Alzheimer’s disease diagnosis.
Image credit: Liao et al
03/04/2026
research article
SARS-CoV-2 infection rates displayed strikingly organized patterns of temporal and spatial spread as new variants were introduced and...
Image credit: Lopes et al
02/20/2026
research article
Resting state fMRI signals in mammals exhibit rich dynamics on a fast, frame-by-frame timescale of seconds...
Image credit: Europeana
01/21/2026
research article
Here the authors present Histo-Miner, a framework designed to systematically analyze these images at multiple levels of detail.
Image credit: Sancéré et al
01/22/2026
research article
The authors use AlphaFold2-multimer to generate high-confidence predictions of PPIs in Drosophila melanogaster.
Image credit: Peng and Zhao
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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