hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA

Jingchen Xu; Hongying Li; Jianrui Li; Biao Dong; Hu Li; Han Sun; Jiayu Zhang; Jiujiao Gao; Yue Gong; Xinyue Liu; Zidie Nian; Tong Wang; Ning Li; Jiandong Jiang; Zonggen Peng

doi:10.1371/journal.ppat.1014491

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Open Access

Peer-reviewed

Research Article

hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA

Jingchen Xu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Hongying Li,

Roles Data curation, Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jianrui Li,

Roles Investigation, Methodology

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Biao Dong,

Roles Methodology, Software

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Hu Li,

Roles Methodology, Supervision

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Han Sun,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jiayu Zhang,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jiujiao Gao,

Roles Writing – review & editing

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Yue Gong,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Xinyue Liu,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Zidie Nian,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Tong Wang,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Ning Li,

Roles Investigation

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jiandong Jiang ,

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: pumcpzg@126.com (ZP), jiang.jdong@163.com (JJ)

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Zonggen Peng

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: pumcpzg@126.com (ZP), jiang.jdong@163.com (JJ)

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

https://orcid.org/0000-0001-7662-6892

⨯

hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA

Jingchen Xu,
Hongying Li,
Jianrui Li,
Biao Dong,
Hu Li,
Han Sun,
Jiayu Zhang,
Jiujiao Gao,
Yue Gong,
Xinyue Liu

Published: August 7, 2026
https://doi.org/10.1371/journal.ppat.1014491

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