Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors

Chaitra Prabhakara; Rashmi Godbole; Parijat Sil; Sowmya Jahnavi; Shah-e-Jahan Gulzar; Thomas S. van Zanten; Dhruv Sheth; Neeraja Subhash; Anchal Chandra; Akshatha Shivaraj; Patricia Panikulam; Ibrahim U; Vijay Kumar Nuthakki; Theja Parassini Puthiyapurayil; Riyaz Ahmed; Ashaq Hussain Najar; Sai Manoz Lingamallu; Snigdhadev Das; Bhagyashri Mahajan; Praveen Vemula; Sandip B. Bharate; Parvinder Pal Singh; Ram Vishwakarma; Arjun Guha; Varadharajan Sundaramurthy; Satyajit Mayor

doi:10.1371/journal.ppat.1009706

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Open Access

Peer-reviewed

Research Article

Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors

Chaitra Prabhakara ,

Contributed equally to this work with: Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-0915-4017

⨯
Rashmi Godbole ,

Contributed equally to this work with: Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations National Centre for Biological Sciences (TIFR), Bengaluru, India, University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, India
⨯
Parijat Sil ,

Contributed equally to this work with: Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0002-8391-8110

⨯
Sowmya Jahnavi ,

Contributed equally to this work with: Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0002-2923-3938

⨯
Shah-e-Jahan Gulzar ,

Contributed equally to this work with: Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar

Roles Conceptualization, Data curation, Investigation, Methodology

Affiliations National Centre for Biological Sciences (TIFR), Bengaluru, India, SASTRA University, Thanjavur, India

https://orcid.org/0000-0003-0489-9888

⨯
Thomas S. van Zanten ,

Roles Data curation, Formal analysis, Software, Visualization, Writing – original draft, Writing – review & editing

¶‡ TSvZ and DS also contributed equally to this work.

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0002-8810-7149

⨯
Dhruv Sheth ,

Roles Data curation, Formal analysis, Software, Visualization

¶‡ TSvZ and DS also contributed equally to this work.

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-2728-3322

⨯
Neeraja Subhash,

Roles Methodology

Affiliations National Centre for Biological Sciences (TIFR), Bengaluru, India, SASTRA University, Thanjavur, India

https://orcid.org/0000-0002-0241-1984

⨯
Anchal Chandra,

Roles Methodology, Writing – review & editing

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-4096-4771

⨯
Akshatha Shivaraj,

Roles Methodology, Validation

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0001-7185-8803

⨯
Patricia Panikulam,

Roles Methodology, Validation

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-0647-0030

⨯
Ibrahim U,

Roles Methodology, Validation

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-1374-8969

⨯
Vijay Kumar Nuthakki,

Roles Methodology

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India

https://orcid.org/0000-0002-7454-1948

⨯
Theja Parassini Puthiyapurayil,

Roles Methodology

Affiliation Institute for Stem Cell Science and Regenerative Medicine (inSTEM), Bengaluru, India
⨯
Riyaz Ahmed,

Roles Methodology

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India
⨯
Ashaq Hussain Najar,

Roles Methodology

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India
⨯
Sai Manoz Lingamallu,

Roles Methodology

Affiliations Institute for Stem Cell Science and Regenerative Medicine (inSTEM), Bengaluru, India, Manipal Academy of Higher Education (MAHE), Madhav Nagar, Manipal, Karnataka, India

https://orcid.org/0000-0002-0555-7727

⨯
Snigdhadev Das,

Roles Methodology, Validation

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-0604-6862

⨯
Bhagyashri Mahajan,

Roles Methodology, Validation

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India
⨯
Praveen Vemula,

Roles Resources, Supervision

Affiliation Institute for Stem Cell Science and Regenerative Medicine (inSTEM), Bengaluru, India
⨯
Sandip B. Bharate,

Roles Resources, Supervision

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India

https://orcid.org/0000-0001-6081-5787

⨯
Parvinder Pal Singh,

Roles Resources, Supervision

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India
⨯
Ram Vishwakarma,

Roles Resources, Supervision

Affiliation CSIR—Indian Institute of Integrative Medicine, Jammu, India

https://orcid.org/0000-0002-0752-6238

⨯
Arjun Guha,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Institute for Stem Cell Science and Regenerative Medicine (inSTEM), Bengaluru, India
⨯
Varadharajan Sundaramurthy ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: varadha@ncbs.res.in(VS); mayor@ncbs.res.in (SM)

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0003-2562-8518

⨯
[ ... ],
Satyajit Mayor

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: varadha@ncbs.res.in(VS); mayor@ncbs.res.in (SM)

Affiliation National Centre for Biological Sciences (TIFR), Bengaluru, India

https://orcid.org/0000-0001-9842-6963

⨯
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Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors

Chaitra Prabhakara,
Rashmi Godbole,
Parijat Sil,
Sowmya Jahnavi,
Shah-e-Jahan Gulzar,
Thomas S. van Zanten,
Dhruv Sheth,
Neeraja Subhash,
Anchal Chandra,
Akshatha Shivaraj

Published: July 12, 2021
https://doi.org/10.1371/journal.ppat.1009706
See the preprint

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