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Open Access
Peer-reviewed
Research Article
Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis
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Benjamin Speich ,
Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Validation, Writing – original draft
* E-mail: benjamin.speich@usb.ch
¶‡ These authors share first authorship on this work.
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Dmitry Gryaznov ,
Roles Conceptualization, Data curation, Project administration, Writing – review & editing
¶‡ These authors share first authorship on this work.
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Jason W. Busse,
Roles Conceptualization, Data curation, Writing – original draft
Affiliations Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada, Department of Anesthesia, McMaster University, Hamilton, Canada
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Viktoria L. Gloy,
Roles Data curation, Project administration, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Szimonetta Lohner,
Roles Data curation, Writing – review & editing
Affiliations Cochrane Hungary, Clinical Centre of the University of Pécs, Medical School, University of Pécs, Pécs, Hungary, Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary
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Katharina Klatte,
Roles Data curation, Writing – review & editing
Affiliation Clinical Trial Unit, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Ala Taji Heravi,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Swiss Tropical and Public Health Institute, Basel, Switzerland
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Nilabh Ghosh,
Roles Data curation, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Hopin Lee,
Roles Data curation, Writing – review & editing
Affiliation Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Anita Mansouri,
Roles Data curation, Writing – review & editing
Affiliation Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Ioana R. Marian,
Roles Data curation, Writing – review & editing
Affiliation Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Ramon Saccilotto,
Roles Data curation, Software, Writing – review & editing
Affiliation Clinical Trial Unit, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Edris Nury,
Roles Data curation, Writing – review & editing
Affiliations Institute for Evidence in Medicine (for Cochrane Germany Foundation), Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany, Department of General Practice and Primary Care, Medical Center Hamburg–Eppendorf–UKE, Hamburg, Germany
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Benjamin Kasenda,
Roles Data curation, Writing – review & editing
Affiliation Department of Medical Oncology, University of Basel and University Hospital Basel, Basel, Switzerland
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Elena Ojeda–Ruiz,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Bioaraba Health Research Institute, Health Prevention, Promotion and Care Area; Osakidetza Basque Health Service, Araba University Hospital, Preventive Medicine Department, Vitoria–Gasteiz, Spain
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Stefan Schandelmaier,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Yuki Tomonaga,
Roles Data curation, Writing – review & editing
Affiliation Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Alain Amstutz,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Swiss Tropical and Public Health Institute, Basel, Switzerland, Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
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Christiane Pauli–Magnus,
Roles Data curation, Writing – review & editing
Affiliation Clinical Trial Unit, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Karin Bischoff,
Roles Data curation, Writing – review & editing
Affiliations Institute for Evidence in Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany
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Katharina Wollmann,
Roles Data curation, Writing – review & editing
Affiliation Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany
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Laura Rehner,
Roles Data curation, Writing – review & editing
Affiliations Institute for Evidence in Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Institute for Nursing Science and Interprofessional Learning, University Medicine Greifswald, Greifswald, Germany
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Joerg J. Meerpohl,
Roles Data curation, Writing – review & editing
Affiliations Institute for Evidence in Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany
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Alain Nordmann,
Roles Data curation, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Jacqueline Wong,
Roles Data curation, Writing – review & editing
Affiliation Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Ngai Chow,
Roles Data curation, Writing – review & editing
Affiliation Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Patrick Jiho Hong,
Roles Data curation, Writing – review & editing
Affiliations Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada, Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada
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Kimberly Mc Cord – De Iaco,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Multifactorial and Complex Diseases Research Area, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy
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Sirintip Sricharoenchai,
Roles Data curation, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Arnav Agarwal,
Roles Data curation, Writing – review & editing
Affiliations Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada, Division of General Internal Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
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Matthias Schwenkglenks,
Roles Data curation, Methodology, Writing – review & editing
Affiliations Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland, Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland
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Lars G. Hemkens,
Roles Data curation, Writing – review & editing
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Meta–Research Innovation Center Berlin (METRICS–B), Berlin Institute of Health, Berlin, Germany, Meta–Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, United States of America
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Erik von Elm,
Roles Conceptualization, Data curation, Methodology, Writing – review & editing
Affiliation Cochrane Switzerland, Centre for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
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Bethan Copsey,
Roles Data curation, Writing – review & editing
Affiliation Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Alexandra N. Griessbach,
Roles Data curation, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Christof Schönenberger,
Roles Data curation, Writing – review & editing
Affiliation Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland
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Dominik Mertz,
Roles Data curation, Writing – review & editing
Affiliations Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada, Department of Medicine, McMaster University, Hamilton, Canada
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Anette Blümle,
Roles Data curation, Project administration, Writing – review & editing
Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, Clinical Trials Unit, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Belinda von Niederhäusern,
Roles Conceptualization, Data curation, Methodology, Writing – review & editing
Affiliations Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary, Roche Pharma AG, Grenzach–Wyhlen, Germany
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Sally Hopewell,
Roles Conceptualization, Data curation, Methodology, Supervision, Writing – review & editing
Affiliation Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
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Ayodele Odutayo,
Roles Conceptualization, Data curation, Methodology, Project administration, Writing – review & editing
Affiliations Oxford Clinical Trials Research Unit / Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael’s Hospital, Toronto, Ontario, Canada
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Matthias Briel
Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft
Affiliations Meta–Research Centre, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis
- Benjamin Speich,
- Dmitry Gryaznov,
- Jason W. Busse,
- Viktoria L. Gloy,
- Szimonetta Lohner,
- Katharina Klatte,
- Ala Taji Heravi,
- Nilabh Ghosh,
- Hopin Lee,
- Anita Mansouri
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- Published: April 27, 2022
- https://doi.org/10.1371/journal.pmed.1003980