March 24, 2026

The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study

In a registry-based study, Pyry Sipilä and colleagues investigate the role of non-infectious mental and physical illnesses in the association between severe infections and dementia using nationwide data from Finland.

Image credit: AiCanvas, Pixabay

03/19/2026

Research Article

Estimating population immunity against serotype-two poliomyelitis from the inactivated polio vaccine in routine immunization across 112 countries: A modelling study

In a modeling study, Elizabeth Gray and colleagues used country-specific data on inactivated polio vaccine schedules and coverage to estimate immunity against serotype-two poliomyelitis across 112 countries for 2024-2031, finding that the 14-39 week immunization schedule is optimal in all countries.

Image credit: Mika Baumeister, Unsplash

Estimating population immunity against serotype-two poliomyelitis from the inactivated polio vaccine in routine immunization across 112 countries: A modelling study

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Browse Issues 2004 – 2026

03/09/2026

Research Article

Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study

In an observational cohort study of women at risk of acquiring HIV, David Mukasa and colleagues report that initiating HIV preexposure prophylaxis did not associate with an increased incidence of sexually transmitted infections.

Image credit: Michał Parzuchowski, Unsplash

Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study

03/26/2026

Research Article

Physical activity across mid-life and mortality outcomes in Australian women: A target trial emulation using a prospective cohort

In a target trial emulation study, Binh Nguyen and colleagues use longitudinally collected data to investigate the impact of physical activity during mid-life on mortality of Australian women later in life.

Image credit: AndrzejRembowski, Pixabay

Physical activity across mid-life and mortality outcomes in Australian women: A target trial emulation using a prospective cohort

03/25/2026

Research Article

Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study

Using mathematical modeling, Adam Akullian and colleagues estimate that increasing age at first sex is a key driver of the decline in HIV incidence among young women in the Rakai Community Cohort Study in Uganda.

Image credit: CLINTON MWEBAZE, Unsplash

03/24/2026

Perspective

Reassessing BMI-based access to joint replacement surgery

In this Perspective, Jonathan Evans and colleagues discuss why restricting access to joint replacement surgery based on BMI alone is not supported by evidence, and highlight how such restrictions risk exacerbating stigma, inequity and avoidable harm to those who would benefit from surgery.

Image credit: Judy Beth Morris, Unsplash

03/26/2026

Research Article

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials

In a meta-analysis, Eliano Navarese and colleagues investigate the effect of early aspirin withdrawal after a percutaneous coronary intervention on risk of myocardial infarction and bleeding using data from randomized trials

Image credit: olenchic, Pixabay

03/19/2026

Research Article

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study

By Husam Abdel-Qadir, Hardil Bhatt and colleagues.

Image credit: Alexandra_Koch, Pixabay

03/26/2026

Research Article

Pain and treatment outcomes after initiating methadone vs buprenorphine among medicare patients with opioid use disorder and comorbid chronic pain: A target trial emulation

By Wei and colleagues.

Image credit: Anthony Tran, Unsplash

03/27/2026

Perspective

The future of medicine in a One Health world

Long recognized as a breakthrough synthetic approach, One Health has been slow and piecemeal to infiltrate medical fields. In this Perspective, John Gittleman argues that it's time for change by taking on a new patient - the environment.

Image credit: Fateme Alaei, Unsplash

03/25/2026

Research Article

Transformer-based deep learning model for real-time prediction of intraoperative hypotension using dynamic time-series vital signs: A retrospective study

By Shouqiang Zhu, Weihai Shi and colleagues.

Image credit: frolicsomepl, pexels

Bacterial Antimicrobial Resistance

Living to our full potential: Reassessing global sex inequalities in life expectancy

In this Perspective article, Ann Weber and Gary Darmstadt discuss how benchmarking life expectancy against what is achievable reveals how sex disadvantage shifts by age, place, and time, and reframes inequality as unrealized potential due to social and structural constraints rather than differences in biology.
Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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