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Toxicology

Overexpression of the translocon accessory protein YajC alleviates toxicity of the endogenous pore-forming toxin LdrA in Escherichia coli

Yuto Nakamura, Yoshihiro Yamaguchi

published 24 Nov 2025

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Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway

Ahmed Abdullah Al Awadh, Elhashimi Eltayb Hassan, Omer Mohamed Shoaib, Osman A.E. Elnoubi, Saadalnour Abusail Mustafa, Yasir Mohammed Althayrayan, Majed Ahmed Althayrayan, Mohammed Merae Alshahrani

published 21 Nov 2025

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Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset

Lucy Grigoroff, Reika Masuda, John Lindon, Janonna Kadyrov, Jeremy K. Nicholson, Elaine Holmes, Julien Wist

published 20 Nov 2025

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Skeletal muscle index, grip strength, and physical performance as predictors of severe chemotherapy toxicity among older adults with malignancy

Efthymios Papadopoulos, Dmitry Rozenberg, Andy Kin On Wong, Sharon Hiu Ching Law, Sarah Costa, Angela M. Cheung, Shabbir M. H. Alibhai

published 19 Nov 2025

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Antitumor and cytotoxic activities of endophytic Enterobacter hormaechei derived secondary metabolites: In-vitro and In-silico study

Muddasir Khan, Sumera Afzal Khan, Chieh-Wei Chang, Chien-Chin Chen, Bokyung Lee, Muhammad Hamayun

published 18 Nov 2025

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NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants

Nasteho Abdoulkader, Jennifer Archibald, Morgane Lignereux, Eric A. Lehoux, Isabelle Catelas

published 18 Nov 2025

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Computational identification of novel SIRT4 inhibitors for diabetic nephropathy using pharmacophore modeling, molecular simulations, and DFT calculations

Wenxiang He, Jianwu Chen

published 17 Nov 2025

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Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine

Hyeon-Jin Na, Yongbo Shin, Seung-Hyun Kim, Seung Pil Jang, Myung Jin Son, Yong Min Choi, Hyeon Gyeol Jeon, Ok-Seon Kwon, Kyung-Sook Chung

published 14 Nov 2025

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First-principles calculation of adsorption of cadmium and lead on the surface of a 1T-MnO₂ monolayer

Julieth V. Dita-Casiano, Mario L. Arteaga-Calderón, Gladys R. Casiano-Jiménez, César Ortega-Lopez, Miguel J. Espitia-Rico

published 14 Nov 2025

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crm12comb: Phase I/II adaptive design for drug combinations based on CRM design through R

Junying Wang, Song Wu, Jie Yang

published 10 Nov 2025

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Health risk assessment of heavy metals in arid soils of the Nile Delta, Egypt using GIS and multivariate statistical analyses

Ehab Hendawy, Abdel-Aziz Belal, Nazih Y. Rebouh, Mohamed S. Shokr, Abd El Aziz S. Sheta, Ahmed M. Saleh, Ayman F. Abou-Hadid

published 10 Nov 2025

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A systematic comparison of patient information leaflets from local and multinational pharmaceutical companies: Assessing content quality and completeness

Abdulaziz Ibrahim Alzarea, Azfar Athar Ishaqui, Muhammad Zeeshan, Abdullah Salah Alanazi, Aseel Awad Alsaidan, Tauqeer Hussain Mallhi, Muhammad Salman, Yusra Habib Khan, Javeria Farooq, Hassan H. Alhassan, Sami I. Alzarea, Omar Awad Alsaidan

published 07 Nov 2025

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GCMS profiling of bioactive phytocompounds from Curculigo orchiodes Gaertn. root extract and evaluation of antioxidant, and antidiabetic activities: A computational drug development approach

Imran Mahmud, Md. Khalid Saifullah, Md. Niaj Morshed, Md. Arju Hossain, Naznin Shahria, Apurba Kumar Barman, Famim Ahmed, Md. Jakaria Islam, Toufiq Ejaj Khan, Nripendra Nath Biswas

published 05 Nov 2025

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