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TGF-beta signaling cascade

Differential protein expression profiles in human sperm from teratozoospermic and normozoospermic men identify LTBP1 and TGF-βR1 as potential biomarkers within the TGF-β signalling pathway

Paweena Kaewman, Sutisa Nudmamud-Thanoi, Patcharada Amatyakul, Chuchard Punsawad, Sittiruk Roytrakul, Samur Thanoi

published 13 Feb 2026

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A TGFB2/TNF-induced in vitro model of proliferative vitreoretinopathy (PVR) using ARPE-19 cells confirms nicotinamide as an inhibitor of EMT and VEGFA secretion

Yuqing Huang, Roland Meister, Migle Lindziute, Maximilian Binter, Jan Tode, Carsten Framme, Heiko Fuchs

published 13 Jan 2026

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TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen, Weidong Li, Xiaolu Jiang, Hongfu Wen, Yuan Shen, Wen Zhang, Yongjian Peng, Guoping Kang

published 29 Aug 2025

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A multi-omics atlas of CAF subtypes reveals apCAF–M2 macrophage interactions driving immune resistance in glioma

Yubo Ren, Dengfeng Lu, Fei Wang, Zixuan Wang, Jinfeng Li, Run Huang, Yue Lu, Aojie Duan, Renjie Shou, Jiangang Liu, Zhouqing Chen, Zhong Wang, Xiaoou Sun

published 11 Aug 2025

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Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate

JES-Rite Michaels, Paul P. R. Iyyanar, Ammar Husami, Andrew M. Vontell, Samantha A. Brugmann, Rolf W. Stottmann

published 09 Jun 2025

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MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration

Xingpeng Zhang, Guang Li, Fang Tan, Tao Yu, Chengping Xu, Kai Li, Feng Zhang, Meiyan Zhang, Jian Wang

published 03 Jan 2025

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SLC2A3 promotes tumor progression through lactic acid-promoted TGF-β signaling pathway in oral squamous cell carcinoma

Wei Jiang, Sheng Xu, Ping Li

published 16 Apr 2024

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A two-step Bayesian network approach to identify key SNPs associated to multiple phenotypic traits in four purebred laying hen lines

Ismalia Bouba, Emiliano A. Videla Rodriguez, V. Anne Smith, Henry van den Brand, T. Bas Rodenburg, Bram Visser

published 28 Mar 2024

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Pharmacophore mapping approach to find anti-cancer phytochemicals with metformin-like activities against transforming growth factor (TGF)-beta receptor I kinase: An in silico study

Rumman Reza, Niaz Morshed, Md. Nazmus Samdani, Md. Selim Reza

published 09 Nov 2023

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Understanding of arthrofibrosis: New explorative insights into extracellular matrix remodeling of synovial fibroblasts

Thanh-Diep Ly, Meike Sambale, Lara Klösener, Philipp Traut, Bastian Fischer, Doris Hendig, Joachim Kuhn, Cornelius Knabbe, Isabel Faust-Hinse

published 26 May 2023

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A phenotype driven integrative framework uncovers molecular mechanisms of a rare hereditary thrombophilia

Noël Malod-Dognin, Gaia Ceddia, Maja Gvozdenov, Branko Tomić, Sofija Dunjić Manevski, Valentina Djordjević, Nataša Pržulj

published 25 Apr 2023

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MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells

Xiaonan Hu, Maximilian Binter, Karsten Hufendiek, Jan Tode, Carsten Framme, Heiko Fuchs

published 28 Nov 2022

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Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor

Mona A. Abu El-Makarem, Mariana F. Kamel, Ahmed A. Mohamed, Hisham A. Ali, Mahmoud R. Mohamed, Alaa El-Deen M. Mohamed, Ahmed M. El-Said, Mahmoud G. Ameen, Alshymaa A. Hassnine, Hatem A. Hassan

published 14 Nov 2022

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