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Synthetic biotherapeutics

A structure-based engineering approach to abrogate pre-existing antibody binding to biotherapeutics

Joanne Lin, Stacey L. Lee, [ ... ], Petra Verdino

Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study

Karen Liao, Keguan Chen, [ ... ], Stephen L. DeWall

Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions

Ben Niu, Michael Martinelli II, [ ... ], Eric Meinke

Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story

Bonita Rup, Sari Alon, [ ... ], Pauline M. Rudd

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics

Marisa K. Joubert, Meghana Deshpande, [ ... ], Vibha Jawa

A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins

Antonios C. Tsolis, Nikos C. Papandreou, Vassiliki A. Iconomidou, Stavros J. Hamodrakas

Sensitive and Specific Detection of the Non-Human Sialic Acid N-Glycolylneuraminic Acid In Human Tissues and Biotherapeutic Products

Sandra L. Diaz, Vered Padler-Karavani, [ ... ], Nissi M. Varki

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