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Substitution mutation

A premature ovarian insufficiency-associated LMD-3 point mutation impairs protein stability and causes autophagic-lysosomal dysfunction in Caenorhabditis elegans

Yile Zhai, Tiantian Wang, Meixi Gong, Yuhan Liang, Wenfei Li, Xin Wang, Zhe Zhang

published 27 Oct 2026

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Mutation-resolved ABL1 inhibitor resistance prediction under mutation-disjoint and temporal cross-study validation

Mohanad A. Deif, Mohamed A. Hafez, Mohammad Khishe, Ahmed Solyman, Ismail A. M. Elhaty

published 27 Oct 2026

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Hepatitis B virus genome mutations in precore and basal core promoter regions among HBeAg-negative chronic hepatitis B patients with high viral load in Indonesia

Dewi Wulandari, Yan Mardian, Sunita, Kadek Aditya Darmayoga, Rindha Agustiani, Khoirunnisa, Youdiil Ophinni

published 15 Sep 2026

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Targeted sequencing provides genetic insights into familial cardiovascular disease among young adults in a high consanguinity population

Nauman Arif, Imran Khan, Taj Ali Khan, Sajjad Ahmad, Fatima Nauman, Gulzar Ahmad, Muhammad Ijaz, Bilal Ahmad, Syed Munawar Hassan, Saima Afaq, Zia Ul Haq

published 13 Aug 2026

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Analysis of the genotyping of circulating strains and characteristics of Glycoprotein E of Varicella-Zoster Virus in Shanxi Province, China

Hongye Liu, Peiyao Lv, Runmeng Ma, Shuping Guo, Ping Zhang, Jiane Guo, Ruihong Gao, Jitao Wang

published 03 Aug 2026

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Engineering of T7 DNA-dependent RNA polymerase with activity at elevated temperature

Svenja Hehn, Julia Gutbrod, Maxi Gutjahr, Andreas Marx

published 20 Jul 2026

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Design and in silico validation of donor DNA for RNA-guided recombinase-mediated knockout of mstnb gene in Labeo rohita

Lukram Sushil Singh, Porkodi Murugesan, Gowhar Iqbal, Nagavara C. Nidarshan, Harini Gunasekaran, Ad. Viralkumar, Kiran D. Rasal, Manoj P. Brahmane, Sunil K. Nayak, Arvind A. Sonwane, Mukunda Goswami

published 15 Jul 2026

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Genetic surveillance of first- and second-line drug-resistant isolates of Mycobacterium tuberculosis in Peru

David Santos-Lázaro, Aiko N. Vigo, Vidia V. Cotrina, Sandra Villar, Alexis Medina, Cynthia Julcapoma, Edson Pacheco, Miriam J. Alarcón, Zully M. Puyén

published 09 Jul 2026

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Featuring the application of biochemistry in dental practice through a self-directed assignment: A descriptive study

Nazlee Sharmin, Ava K. Chow

published 10 Apr 2026

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Genetic analysis of F1 cluster phages that infect Mycobacterium smegmatis identifies two distinct holin-like proteins that regulate the host lysis event

Richard S. Pollenz, Kira Ruiz-Houston, Wynter Dean, Loc Nguyen

published 07 Apr 2026

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Computational prediction of binding affinity and structural impact of three Pakistani SARS-CoV-2 spike RBD variants on human ACE2 interaction

Muhammad Usama, Muhammad Azeem, Ghulam Mustafa

published 01 Apr 2026

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Internal gene segments from a mouse-adapted influenza B virus confer increased pathogenicity to mice

Arne Matthys, Laura Amelinck, Anouk Smet, Tine Ysenbaert, Thorsten U. Vogel, Xavier Saelens, João Paulo Portela Catani

published 23 Mar 2026

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Near Neutral Selectionist Theories (NNST) for SARS-CoV-2 suggested by the substitution-mutation ratio (c/µ) analysis

Chun Wu, Nicholas J. Paradis

published 04 Mar 2026

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