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Substantia nigra

GDNF receptor GFRα1 is necessary for the maintenance of dopaminergic neurons in the adult substantia nigra

Alvaro Carrier-Ruiz, Annika Andersson, Diana Fernández-Suárez, Carlos F. Ibáñez

published 04 Sep 2025

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Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson’s disease-related phenotypes in a novel humanized rat model

Nicole K. Polinski, Jukka Puoliväli, Leena Rauhala, Taina-Kaisa Stenius, Timo Bragge, Teija Parkkari, Anna-Maija Penttinen, Yi Chen, Omar S. Mabrouk, Kelly E. Glajch, Warren D. Hirst, Michael Perkinton, Terina N. Martinez, Mark A. Frasier

published 08 Aug 2025

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Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson’s disease

Nehal Shawky Nagy, Mohamed Helal, Eman Sheta Alsawy, Mohamad Moustafa Ali, Soheir Salem Al-Sherif, Amina Essawy Essawy

published 18 Dec 2024

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Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures

Mark J. Connolly, Sujin Jiang, Lim C. Samuel, Claire-Anne Gutekunst, Robert E. Gross, Annaelle Devergnas

published 28 Aug 2024

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Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?

Simone Steinbach, Mariana Molina, Lea T. Grinberg, Luisa Aring, Annika Guntermann, Katrin Marcus, Helmut Heinsen, Renata E. Paraizo Leite, Caroline May

published 31 Jul 2024

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Benfotiamine protects MPTP-induced Parkinson’s disease mouse model via activating Nrf2 signaling pathway

Kai Wang, Chao Han, Jinwei Yang, Wenhao Xu, Lei Wang, Huaiyu Li, Yu Wang

published 23 Jul 2024

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Identification of potential immune-related hub genes in Parkinson’s disease based on machine learning and development and validation of a diagnostic classification model

Guanghao Xin, Jingyan Niu, Qinghua Tian, Yanchi Fu, Lixia Chen, Tingting Yi, Kuo Tian, Xuesong Sun, Na Wang, Jianjian Wang, Huixue Zhang, Lihua Wang

published 05 Dec 2023

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Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein

Yu-Sung Chiu, Kuo-Jen Wu, Seong-Jin Yu, Kun-Lieh Wu, Yu-Syuan Wang, Jing Lin, Chia-Ying Chu, Shuchun Chen, Hsi Chen, Shu-Ching Hsu, Yun Wang, Yun-Hsiang Chen

published 21 Sep 2023

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Absolute quantification of neuromelanin in formalin-fixed human brains using absorbance spectrophotometry

Dipshay Avi Chand, Miriam Scadeng, Birger Victor Dieriks

published 10 Jul 2023

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In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts

Kristy S. Hwang, Jason Langley, Richa Tripathi, Xiaoping P. Hu, Daniel E. Huddleston

published 13 Apr 2023

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Volumetric assessment and longitudinal changes of subcortical structures in formalinized Beagle brains

Francesca Del Signore, Germain Arribarat, Leonardo Della Salda, Giovanni Mogicato, Alexandra Deviers, Benjamin Cartiaux, Massimo Vignoli, Patrice Peran, Francesco de Pasquale

published 07 Oct 2022

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l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

Toyoshi Umezu, Tomoharu Sano, Junko Hayashi

published 30 Nov 2021

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Measurement of the adult human midbrain with transcranial ultrasound

Karl Aoun, Kay L. Double, Verity Pearson-Dennett, Rezzak Yilmaz, Daniela Berg, Gabrielle Todd

published 01 Mar 2021

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