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Spliceosomes

Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity

Mina Obuća, Zuzana Cvačková, Jan Kubovčiak, Michal Kolář, David Staněk

published 06 Apr 2022

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The influence of 4-thiouridine labeling on pre-mRNA splicing outcomes

Jessie A. C. Altieri, Klemens J. Hertel

published 13 Dec 2021

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U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors

Veronica K. Urabe, Meredith Stevers, Arun K. Ghosh, Melissa S. Jurica

published 14 Oct 2021

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The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death

Erin J. Vanzyl, Hadil Sayed, Alex B. Blackmore, Kayleigh R. C. Rick, Pasan Fernando, Bruce C. McKay

published 28 Dec 2020

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Comparative proteomics analysis of dietary restriction in Drosophila

Yue Gao, Chenxing Zhu, Keqin Li, Xingyi Cheng, Yanjiao Du, Deying Yang, Xiaolan Fan, Uma Gaur, Mingyao Yang

published 16 Oct 2020

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Clinical interpretation of variants identified in RNU4ATAC, a non-coding spliceosomal gene

Clara Benoit-Pilven, Alicia Besson, Audrey Putoux, Claire Benetollo, Clément Saccaro, Justine Guguin, Gabriel Sala, Audric Cologne, Marion Delous, Gaetan Lesca, Richard A. Padgett, Anne-Louise Leutenegger, Vincent Lacroix, Patrick Edery, Sylvie Mazoyer

published 06 Jul 2020

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, Alexander J. Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R. Scott Lokey, Thomas R. Webb

published 29 May 2020

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Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing

Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W. Guo, Guorong Xu, Roman Sasik, Kathleen M. Fisch, J. Silvio Gutkind, Elana J. Fertig, Alfredo A. Molinolo, Joseph A. Califano

published 21 May 2020

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Impact of cancer-associated mutations in Hsh155/SF3b1 HEAT repeats 9-12 on pre-mRNA splicing in Saccharomyces cerevisiae

Harpreet Kaur, Brent Groubert, Joshua C. Paulson, Sarah McMillan, Aaron A. Hoskins

published 22 Apr 2020

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Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

Wim Trypsteen, Cory H. White, Amey Mukim, Celsa A. Spina, Ward De Spiegelaere, Steve Lefever, Vicente Planelles, Alberto Bosque, Christopher H. Woelk, Linos Vandekerckhove, Nadejda Beliakova-Bethell

published 11 Nov 2019

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Transcriptome analysis of Macrobrachium rosenbergii intestines under the white spot syndrome virus and poly (I:C) challenges

Zhengfeng Ding, Min Jin, Qian Ren

published 28 Sep 2018

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Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin

Erin J. Vanzyl, Kayleigh R. C. Rick, Alex B. Blackmore, Erin M. MacFarlane, Bruce C. McKay

published 16 Jan 2018

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Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

Martin Grundy, Claire Seedhouse, Thomas Jones, Liban Elmi, Michael Hall, Adam Graham, Nigel Russell, Monica Pallis

published 03 Jan 2018

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