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Small molecules

Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1

Ryan G. Thomas, Brenda M. Rivera Reyes, Benjamin M. Gaston, Nelki B. Rivera Acosta, Ilya R. Bederman, Laura A. Smith, Morgan T. Sutton, Benlian Wang, John F. Hunt, Tracey L. Bonfield

published 11 Dec 2017

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Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma

Jinsoo Oh, Yongbo Kim, Lihua Che, Jeong Beom Kim, Gyeong Eon Chang, Eunji Cheong, Seok-Gu Kang, Yoon Ha

published 21 Nov 2017

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Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Natalia Platonova, Chiara Parravicini, Cristina Sensi, Alessandro Paoli, Michela Colombo, Antonino Neri, Ivano Eberini, Raffaella Chiaramonte

published 03 Nov 2017

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Levels of L-malate and other low molecular weight metabolites in spores of Bacillus species and Clostridium difficile

George Korza, Stephen Abini-Agbomson, Barbara Setlow, Aimee Shen, Peter Setlow

published 29 Aug 2017

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Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes

Margarite D. Matossian, Steven Elliott, Van T. Hoang, Hope E. Burks, Theresa B. Phamduy, Douglas B. Chrisey, William J. Zuercher, David H. Drewry, Carrow Wells, Bridgette Collins-Burow, Matthew E. Burow

published 03 Aug 2017

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Progress towards a public chemogenomic set for protein kinases and a call for contributions

David H. Drewry, Carrow I. Wells, David M. Andrews, Richard Angell, Hassan Al-Ali, Alison D. Axtman, Stephen J. Capuzzi, Jonathan M. Elkins, Peter Ettmayer, Mathias Frederiksen, Opher Gileadi, Nathanael Gray, Alice Hooper, Stefan Knapp, Stefan Laufer, Ulrich Luecking, Michael Michaelides, Susanne Müller, Eugene Muratov, R. Aldrin Denny, Kumar S. Saikatendu, Daniel K. Treiber, William J. Zuercher, Timothy M. Willson

published 02 Aug 2017

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A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

Cristina St. Pierre, Jane Guo, John D. Shin, Laura W. Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J. Michael Ellis, Hani Houshyar, Michael A. Crackower, Melanie A. Kleinschek, Dallas C. Jones, Alexandra Hicks, Dennis M. Zaller, Stephen E. Alves, Ravisankar A. Ramadas

published 18 Jul 2017

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Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Akito Ono, Osamu Sano, Ken-ichi Kazetani, Takamichi Muraki, Keisuke Imamura, Hiroyuki Sumi, Junji Matsui, Hidehisa Iwata

published 13 Jul 2017

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Protocols for the delivery of small molecules to the two-spotted spider mite, Tetranychus urticae

Takeshi Suzuki, María Urizarna España, Maria Andreia Nunes, Vladimir Zhurov, Wannes Dermauw, Masahiro Osakabe, Thomas Van Leeuwen, Miodrag Grbic, Vojislava Grbic

published 07 Jul 2017

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Construction of an enantiopure bivalent nicotine vaccine using synthetic peptides

David F. Zeigler, Richard Roque, Christopher H. Clegg

published 01 Jun 2017

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Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

Hung Yi Kristal Kaan, Adelene Y. L. Sim, Siew Kim Joyce Tan, Chandra Verma, Haiwei Song

published 01 Jun 2017

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Timelines of translational science: From technology initiation to FDA approval

Laura M. McNamee, Michael Jay Walsh, Fred D. Ledley

published 08 May 2017

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Small molecule inhibitors of mesotrypsin from a structure-based docking screen

Olumide Kayode, Zunnan Huang, Alexei S. Soares, Thomas R. Caulfield, Zigang Dong, Ann M. Bode, Evette S. Radisky

published 02 May 2017

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