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Small molecules

High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

Joost Schulte, Katharine J. Sepp, [ ... ], J. Troy Littleton

DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells

Ada Ao, Jijun Hao, Corey R. Hopkins, Charles C. Hong

Rift Valley Fever Virus Infection of Human Cells and Insect Hosts Is Promoted by Protein Kinase C Epsilon

Claire Marie Filone, Sheri L. Hanna, [ ... ], Sara Cherry

GPU-Accelerated Molecular Dynamics Simulation to Study Liquid Crystal Phase Transition Using Coarse-Grained Gay-Berne Anisotropic Potential

Wenduo Chen, Youliang Zhu, [ ... ], Yunqi Li

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Bhuvanesh Dave, Melissa D. Landis, [ ... ], Jenny C. Chang

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

Jonathan A. Lee, Paul Shinn, [ ... ], Craig J. Thomas

A Simple and Fast Non-Radioactive Bridging Immunoassay for Insulin Autoantibodies

Ingrid Kikkas, Roberto Mallone, [ ... ], Nathalie Morel

An In Silico Analysis of the Binding Modes and Binding Affinities of Small Molecule Modulators of PDZ-Peptide Interactions

Garima Tiwari, Debasisa Mohanty

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

Nanda Kumar Sasi, Kanchan Tiwari, [ ... ], Michael Weinreich

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Young Do Kwon, Judith M. LaLonde, [ ... ], Peter D. Kwong

Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

Bilal Çakir, Onur Dağliyan, [ ... ], Metin Türkay

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

Chongzhao Ran, Wei Zhao, Robert D. Moir, Anna Moore

Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions

Fatema Z. Chowdhury, Leonardo D. Estrada, [ ... ], J. David Farrar

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