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Small molecules

High content, high-throughput screening for small molecule inducers of NF-κB translocation

Samuel Njikan, Alyssa J. Manning, Yulia Ovechkina, Divya Awasthi, Tanya Parish

published 28 Jun 2018

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Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment

Shenda Gu, Worapol Ngamcherdtrakul, Moataz Reda, Zhi Hu, Joe W. Gray, Wassana Yantasee

published 07 Jun 2018

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A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

Amir Hossein Daneshmanesh, Mohammad Hojjat-Farsangi, Amineh Ghaderi, Ali Moshfegh, Lotta Hansson, Johan Schultz, Jan Vågberg, Styrbjörn Byström, Elisabeth Olsson, Thomas Olin, Anders Österborg, Håkan Mellstedt

published 01 Jun 2018

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Differentially abundant proteins associated with heterosis in the primary roots of popcorn

Mathias F. Rockenbach, Caio C. G. Corrêa, Angelo S. Heringer, Ismael L. J. Freitas, Claudete Santa-Catarina, Antônio T. do Amaral-Júnior, Vanildo Silveira

published 14 May 2018

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Biophysical characterization of hit compounds for mechanism-based enzyme activation

Xiangying Guan, Alok Upadhyay, Sudipto Munshi, Raj Chakrabarti

published 16 Mar 2018

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The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent

Ross Ferguson, Vasanta Subramanian

published 27 Feb 2018

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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Katharina Schrade, Jessica Tröger, Adeeb Eldahshan, Kerstin Zühlke, Kamal R. Abdul Azeez, Jonathan M. Elkins, Martin Neuenschwander, Andreas Oder, Mohamed Elkewedi, Sarah Jaksch, Karsten Andrae, Jinliang Li, Joao Fernandes, Paul Markus Müller, Stephan Grunwald, Stephen F. Marino, Tanja Vukićević, Jenny Eichhorst, Burkhard Wiesner, Marcus Weber, Michael Kapiloff, Oliver Rocks, Oliver Daumke, Thomas Wieland, Stefan Knapp, Jens Peter von Kries, Enno Klussmann

published 26 Jan 2018

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Unraveling the novel effects of aroma from small molecules in preventing hen egg white lysozyme amyloid fibril formation

Zahra Seraj, Arefeh Seyedarabi, Ali Akbar Saboury, Mehran Habibi-Rezaei, Shahin Ahmadian, Atiyeh Ghasemi

published 22 Jan 2018

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Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

Joey P. Ting, Frances Tung, Stephen Antonysamy, Stephen Wasserman, Spencer B. Jones, Feiyu F. Zhang, Alfonso Espada, Howard Broughton, Michael J. Chalmers, Michael E. Woodman, Holly A. Bina, Jeffrey A. Dodge, Jordi Benach, Aiping Zhang, Christopher Groshong, Danalyn Manglicmot, Marijane Russell, Sepideh Afshar

published 12 Jan 2018

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Biologicals and small molecules in psoriasis: A systematic review of economic evaluations

Christian Kromer, Daniel Celis, Diana Sonntag, Wiebke K. Peitsch

published 03 Jan 2018

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Small molecules targeting LapB protein prevent Listeria attachment to catfish muscle

Ali Akgul, Nawar Al-Janabi, Bhaskar Das, Mark Lawrence, Attila Karsi

published 18 Dec 2017

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Quantifying male and female pheromone-based mate choice in Caenorhabditis nematodes using a novel microfluidic technique

Flora Borne, Katja R. Kasimatis, Patrick C. Phillips

published 13 Dec 2017

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Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C. Robinson, David P. Lane, Christopher J. Brown, Farid J. Ghadessy

published 11 Dec 2017

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