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Small molecules

Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib

Mona M. Al-Shehri, Adel S. El-Azab, Manal A. El-Gendy, Mohammed A. Hamidaddin, Ibrahim A. Darwish

published 11 Feb 2019

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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers, Tomasz Kulikowicz, Deborah L. Croteau, Thomas Dexheimer, Dorjbal Dorjsuren, Ajit Jadhav, David J. Maloney, Anton Simeonov, Vilhelm A. Bohr, Robert M. Brosh Jr.

published 09 Jan 2019

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Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene

Sascha Stump, Tung-Chung Mou, Stephen R. Sprang, Nicholas R. Natale, Howard D. Beall

published 12 Oct 2018

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Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

Matthias Steinfath, Silvia Vogl, Norman Violet, Franziska Schwarz, Hans Mielke, Thomas Selhorst, Matthias Greiner, Gilbert Schönfelder

published 12 Sep 2018

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Harnessing the biological complexity of Big Data from LINCS gene expression signatures

Aliyu Musa, Shailesh Tripathi, Meenakshisundaram Kandhavelu, Matthias Dehmer, Frank Emmert-Streib

published 29 Aug 2018

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Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V. Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A. Youker, Suresh S. Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L. Spiller, Kenichi Watanabe, Rajarajan A. Thandavarayan

published 19 Jul 2018

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Construction of an integrated database for hERG blocking small molecules

Tomohiro Sato, Hitomi Yuki, Keiji Ogura, Teruki Honma

published 06 Jul 2018

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High content, high-throughput screening for small molecule inducers of NF-κB translocation

Samuel Njikan, Alyssa J. Manning, Yulia Ovechkina, Divya Awasthi, Tanya Parish

published 28 Jun 2018

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Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment

Shenda Gu, Worapol Ngamcherdtrakul, Moataz Reda, Zhi Hu, Joe W. Gray, Wassana Yantasee

published 07 Jun 2018

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A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

Amir Hossein Daneshmanesh, Mohammad Hojjat-Farsangi, Amineh Ghaderi, Ali Moshfegh, Lotta Hansson, Johan Schultz, Jan Vågberg, Styrbjörn Byström, Elisabeth Olsson, Thomas Olin, Anders Österborg, Håkan Mellstedt

published 01 Jun 2018

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Differentially abundant proteins associated with heterosis in the primary roots of popcorn

Mathias F. Rockenbach, Caio C. G. Corrêa, Angelo S. Heringer, Ismael L. J. Freitas, Claudete Santa-Catarina, Antônio T. do Amaral-Júnior, Vanildo Silveira

published 14 May 2018

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Biophysical characterization of hit compounds for mechanism-based enzyme activation

Xiangying Guan, Alok Upadhyay, Sudipto Munshi, Raj Chakrabarti

published 16 Mar 2018

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The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent

Ross Ferguson, Vasanta Subramanian

published 27 Feb 2018

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