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Small molecules

Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib

Mona M. Al-Shehri, Adel S. El-Azab, [ ... ], Ibrahim A. Darwish

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers, Tomasz Kulikowicz, [ ... ], Robert M. Brosh Jr.

Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene

Sascha Stump, Tung-Chung Mou, [ ... ], Howard D. Beall

Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

Matthias Steinfath, Silvia Vogl, [ ... ], Gilbert Schönfelder

Harnessing the biological complexity of Big Data from LINCS gene expression signatures

Aliyu Musa, Shailesh Tripathi, [ ... ], Frank Emmert-Streib

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Vengadeshprabhu Karuppagounder, Anamika Bajpai, [ ... ], Rajarajan A. Thandavarayan

Construction of an integrated database for hERG blocking small molecules

Tomohiro Sato, Hitomi Yuki, Keiji Ogura, Teruki Honma

High content, high-throughput screening for small molecule inducers of NF-κB translocation

Samuel Njikan, Alyssa J. Manning, [ ... ], Tanya Parish

Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment

Shenda Gu, Worapol Ngamcherdtrakul, [ ... ], Wassana Yantasee

A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

Amir Hossein Daneshmanesh, Mohammad Hojjat-Farsangi, [ ... ], Håkan Mellstedt

Differentially abundant proteins associated with heterosis in the primary roots of popcorn

Mathias F. Rockenbach, Caio C. G. Corrêa, [ ... ], Vanildo Silveira

Biophysical characterization of hit compounds for mechanism-based enzyme activation

Xiangying Guan, Alok Upadhyay, Sudipto Munshi, Raj Chakrabarti

The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent

Ross Ferguson, Vasanta Subramanian

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