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Small molecules

FDA orphan drug designations for lysosomal storage disorders – a cross-sectional analysis

Sven F. Garbade, Matthias Zielonka, [ ... ], Markus Ries

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, [ ... ], Thomas W. Miller

Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer

Yan Zhang, Andrei Pavlov, [ ... ], Hui Ge

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, [ ... ], Jingwei Tian

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Hans E. Hohmeier, Lu Zhang, [ ... ], Christopher B. Newgard

IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

Anjelika Gasilina, Gurdat Premnauth, [ ... ], Nicolas N. Nassar

Effect of small molecule signaling in PepFect14 transfection

Maxime Gestin, Henrik Helmfors, [ ... ], Ülo Langel

Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations

Frank Guarnieri, John L. Kulp Jr., John L. Kulp III, Ian S. Cloudsdale

The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman, Roberto Romero, [ ... ], Offer Erez

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Stephanie Szobota, Pranav D. Mathur, [ ... ], Alan C. Foster

Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine

E. J. Putz, A. M. Putz, [ ... ], C. K. Tuggle

IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate

Adam M. Corrigan, Johan Karlsson, [ ... ], Yinhai Wang

Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors

Rebecca L. Switzer, Jessica Medrano, David A. Reedel, Jill Weiss

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