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Small molecules

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Hans E. Hohmeier, Lu Zhang, Brandon Taylor, Samuel Stephens, Danhong Lu, Peter McNamara, Bryan Laffitte, Christopher B. Newgard

published 16 Mar 2020

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IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

Anjelika Gasilina, Gurdat Premnauth, Purujit Gurjar, Jacek Biesiada, Shailaja Hegde, David Milewski, Gang Ma, Tanya V. Kalin, Edward Merino, Jarek Meller, William Seibel, José A. Cancelas, Lisa Privette Vinnedge, Nicolas N. Nassar

published 12 Mar 2020

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Effect of small molecule signaling in PepFect14 transfection

Maxime Gestin, Henrik Helmfors, Luca Falato, Nicola Lorenzon, Filip Ilias Michalakis, Ülo Langel

published 30 Jan 2020

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Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations

Frank Guarnieri, John L. Kulp Jr., John L. Kulp III, Ian S. Cloudsdale

published 05 Dec 2019

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The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman, Roberto Romero, Adi L. Tarca, Percy Pacora, Brian Ingram, Eli Maymon, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Offer Erez

published 14 Nov 2019

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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Stephanie Szobota, Pranav D. Mathur, Sairey Siegel, KristenAnn Black, H. Uri Saragovi, Alan C. Foster

published 31 Oct 2019

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Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine

E. J. Putz, A. M. Putz, A. Boettcher, S. Charley, M. Sauer, M. Palmer, R. Phillips, J. Hostetter, C. L. Loving, J. E. Cunnick, C. K. Tuggle

published 09 Oct 2019

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IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate

Adam M. Corrigan, Johan Karlsson, Jan Wildenhain, Laurent Knerr, Maria Ölwegård-Halvarsson, Maria Karlsson, Svenja Lünse, Yinhai Wang

published 01 Aug 2019

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Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors

Rebecca L. Switzer, Jessica Medrano, David A. Reedel, Jill Weiss

published 15 Jul 2019

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Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

Thomas W. Miller, Joshua D. Amason, Elsa D. Garcin, Laurence Lamy, Patricia K. Dranchak, Ryan Macarthur, John Braisted, Jeffrey S. Rubin, Teresa L. Burgess, Catherine L. Farrell, David D. Roberts, James Inglese

published 05 Jul 2019

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Identifying small molecule probes of ENTPD5 through high throughput screening

Matthew A. Durst, Kiira Ratia, Arnon Lavie

published 26 Jun 2019

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Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors

Devashree N. Patil, Sushama A. Patil, Srinivas Sistla, Jyoti P. Jadhav

published 31 May 2019

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Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib

Mona M. Al-Shehri, Adel S. El-Azab, Manal A. El-Gendy, Mohammed A. Hamidaddin, Ibrahim A. Darwish

published 11 Feb 2019

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