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Small molecules

FDA orphan drug designations for lysosomal storage disorders – a cross-sectional analysis

Sven F. Garbade, Matthias Zielonka, Konstantin Mechler, Stefan Kölker, Georg F. Hoffmann, Christian Staufner, Eugen Mengel, Markus Ries

published 08 Apr 2020

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A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer

Yan Zhang, Andrei Pavlov, Sohail Malik, Hong Chen, Nancy Kim, Ziqing Li, Xiaohong Zhang, Melvin L. DePamphilis, Robert G. Roeder, Hui Ge

published 31 Mar 2020

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PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, Guangying Du, Wenyan Wang, Haibo Zhu, Ning Li, Huijuan Zhao, Zhaoju Dong, Liang Ye, Jingwei Tian

published 26 Mar 2020

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Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Hans E. Hohmeier, Lu Zhang, Brandon Taylor, Samuel Stephens, Danhong Lu, Peter McNamara, Bryan Laffitte, Christopher B. Newgard

published 16 Mar 2020

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IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

Anjelika Gasilina, Gurdat Premnauth, Purujit Gurjar, Jacek Biesiada, Shailaja Hegde, David Milewski, Gang Ma, Tanya V. Kalin, Edward Merino, Jarek Meller, William Seibel, José A. Cancelas, Lisa Privette Vinnedge, Nicolas N. Nassar

published 12 Mar 2020

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Effect of small molecule signaling in PepFect14 transfection

Maxime Gestin, Henrik Helmfors, Luca Falato, Nicola Lorenzon, Filip Ilias Michalakis, Ülo Langel

published 30 Jan 2020

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Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations

Frank Guarnieri, John L. Kulp Jr., John L. Kulp III, Ian S. Cloudsdale

published 05 Dec 2019

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The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman, Roberto Romero, Adi L. Tarca, Percy Pacora, Brian Ingram, Eli Maymon, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Offer Erez

published 14 Nov 2019

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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Stephanie Szobota, Pranav D. Mathur, Sairey Siegel, KristenAnn Black, H. Uri Saragovi, Alan C. Foster

published 31 Oct 2019

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Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine

E. J. Putz, A. M. Putz, A. Boettcher, S. Charley, M. Sauer, M. Palmer, R. Phillips, J. Hostetter, C. L. Loving, J. E. Cunnick, C. K. Tuggle

published 09 Oct 2019

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IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate

Adam M. Corrigan, Johan Karlsson, Jan Wildenhain, Laurent Knerr, Maria Ölwegård-Halvarsson, Maria Karlsson, Svenja Lünse, Yinhai Wang

published 01 Aug 2019

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Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors

Rebecca L. Switzer, Jessica Medrano, David A. Reedel, Jill Weiss

published 15 Jul 2019

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