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Small molecules

A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin

Ruijie Zhang, Xiaozhi Yang, Dana M. Roque, Chenglong Li, Jiayuh Lin

published 28 Apr 2021

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POT1 stability and binding measured by fluorescence thermal shift assays

Lynn W. DeLeeuw, Robert C. Monsen, Vytautas Petrauskas, Robert D. Gray, Lina Baranauskiene, Daumantas Matulis, John O. Trent, Jonathan B. Chaires

published 30 Mar 2021

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Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David, David J. Riese, II

published 30 Dec 2020

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The effects of selected biologics and a small molecule on Health-Related Quality of Life in adult plaque psoriasis patients: A systematic review and meta-analysis

Anna Karpińska-Mirecka, Joanna Bartosińska, Dorota Krasowska

published 03 Dec 2020

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How long do new medicines take to reach Canadian patients after companies file a submission: A cohort study

Joel Lexchin

published 02 Nov 2020

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Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells

Yuzo Takayama, Yuka Akagi, Yoichiro Shibuya, Yasuyuki S. Kida

published 26 Oct 2020

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Assessing multiple score functions in Rosetta for drug discovery

Shannon T. Smith, Jens Meiler

published 12 Oct 2020

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Pressure regulated basis for gene transcription by delta-cell micro-compliance modeled in silico: Biphenyl, bisphenol and small molecule ligand models of cell contraction-expansion

Hemant Sarin

published 06 Oct 2020

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A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS

Taylor R. Nicholas, Jingwei Meng, Benjamin M. Greulich, Teresa Stevie Morris, Peter C. Hollenhorst

published 11 Sep 2020

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G10 is a direct activator of human STING

Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya

published 10 Sep 2020

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A novel pre-clinical antibacterial pipeline database

Sarah Paulin, Richard A. Alm, Peter Beyer

published 28 Jul 2020

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, Alexander J. Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R. Scott Lokey, Thomas R. Webb

published 29 May 2020

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A compound attributes-based predictive model for drug induced liver injury in humans

Yang Liu, Hua Gao, Yudong D. He

published 15 Apr 2020

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