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Small molecules

How long do new medicines take to reach Canadian patients after companies file a submission: A cohort study

Joel Lexchin

published 02 Nov 2020

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Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells

Yuzo Takayama, Yuka Akagi, Yoichiro Shibuya, Yasuyuki S. Kida

published 26 Oct 2020

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Assessing multiple score functions in Rosetta for drug discovery

Shannon T. Smith, Jens Meiler

published 12 Oct 2020

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Pressure regulated basis for gene transcription by delta-cell micro-compliance modeled in silico: Biphenyl, bisphenol and small molecule ligand models of cell contraction-expansion

Hemant Sarin

published 06 Oct 2020

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A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS

Taylor R. Nicholas, Jingwei Meng, Benjamin M. Greulich, Teresa Stevie Morris, Peter C. Hollenhorst

published 11 Sep 2020

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G10 is a direct activator of human STING

Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya

published 10 Sep 2020

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A novel pre-clinical antibacterial pipeline database

Sarah Paulin, Richard A. Alm, Peter Beyer

published 28 Jul 2020

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, Alexander J. Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R. Scott Lokey, Thomas R. Webb

published 29 May 2020

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A compound attributes-based predictive model for drug induced liver injury in humans

Yang Liu, Hua Gao, Yudong D. He

published 15 Apr 2020

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FDA orphan drug designations for lysosomal storage disorders – a cross-sectional analysis

Sven F. Garbade, Matthias Zielonka, Konstantin Mechler, Stefan Kölker, Georg F. Hoffmann, Christian Staufner, Eugen Mengel, Markus Ries

published 08 Apr 2020

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A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer

Yan Zhang, Andrei Pavlov, Sohail Malik, Hong Chen, Nancy Kim, Ziqing Li, Xiaohong Zhang, Melvin L. DePamphilis, Robert G. Roeder, Hui Ge

published 31 Mar 2020

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PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, Guangying Du, Wenyan Wang, Haibo Zhu, Ning Li, Huijuan Zhao, Zhaoju Dong, Liang Ye, Jingwei Tian

published 26 Mar 2020

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