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Small molecules

The effects of selected biologics and a small molecule on Health-Related Quality of Life in adult plaque psoriasis patients: A systematic review and meta-analysis

Anna Karpińska-Mirecka, Joanna Bartosińska, Dorota Krasowska

How long do new medicines take to reach Canadian patients after companies file a submission: A cohort study

Joel Lexchin

Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells

Yuzo Takayama, Yuka Akagi, Yoichiro Shibuya, Yasuyuki S. Kida

Assessing multiple score functions in Rosetta for drug discovery

Shannon T. Smith, Jens Meiler

Pressure regulated basis for gene transcription by delta-cell micro-compliance modeled in silico: Biphenyl, bisphenol and small molecule ligand models of cell contraction-expansion

Hemant Sarin

A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS

Taylor R. Nicholas, Jingwei Meng, [ ... ], Peter C. Hollenhorst

G10 is a direct activator of human STING

Monali Banerjee, Sandip Middya, [ ... ], Arjun Surya

A novel pre-clinical antibacterial pipeline database

Sarah Paulin, Richard A. Alm, Peter Beyer

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, [ ... ], Thomas R. Webb

A compound attributes-based predictive model for drug induced liver injury in humans

Yang Liu, Hua Gao, Yudong D. He

FDA orphan drug designations for lysosomal storage disorders – a cross-sectional analysis

Sven F. Garbade, Matthias Zielonka, [ ... ], Markus Ries

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, [ ... ], Thomas W. Miller

Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer

Yan Zhang, Andrei Pavlov, [ ... ], Hui Ge

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