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Small molecules

Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity

Craig Eyster, Satoshi Matsuzaki, [ ... ], Kenneth M. Humphries

Development of a sequential laser microdissection tissue cuts workflow for the spatial and quantitative analysis of drugs in fresh frozen tissue sections

Elias Maris, Farid Jahouh, Kathleen Allaerts, Rob Vreeken

Virtual screening and molecular dynamics simulation study of ATP-competitive inhibitors targeting mTOR protein

Mei-Yu Jin, Hao Yu, [ ... ], Hui Liang

Feasibility of the inhibitor development for cancer: A systematic approach for drug design

Yu Jiang, Ling Liu, [ ... ], Jianping Hu

In silico analysis to explore the therapeutic potential of propolis-derived small molecules as matriptase inhibitors to suppress breast cancer growth and metastasis

Muhammad Bilal Azmi, Han Yu, [ ... ], Mohnad Abdalla

Administration of novobiocin and apomorphine mitigates cholera toxin mediated cellular toxicity: Lessons from cholera toxin yeast model system

Sonali Eknath Bhalerao, Himanshu Sen, Saumya Raychaudhuri

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs: A WEB prediction approach

Huaichuan Duan, Quanshan Shi, [ ... ], Hubing Shi

Cheminformatics-driven discovery of natural isoquinoline alkaloid inhibitors of Beta-secretase I for Alzheimer’s management

Iqra Ahmad, Sara Waheed, [ ... ], Mohibullah Shah

Sustained intestinal epithelial monolayer wound closure after transient application of a FAK-activating small molecule

Sema Oncel, Qinggang Wang, [ ... ], Marc D. Basson

The endometrial cancer A230V-ALK5 (TGFBR1) mutant attenuates TGF-β signaling and exhibits reduced in vitro sensitivity to ALK5 inhibitors

Eun-Jeong Yu, Daphne W. Bell

Phenotypic profiling of small molecules using cell painting assay in HCT116 colorectal cancer cells

Velemir Lavrinenko, Ilona Donskaya, [ ... ], Stanislav Tyazhelnikov

Study on the releasing regularity of asphalt fume and its suppression technology

Guang Yang, Yongli Xu, Xiaolei Jiao, Yiming Li

Long-term functional rescue of trauma-induced vision loss by a novel, small molecule TrkB modulator

Shweta Modgil, Christopher L. Walker, [ ... ], P. Michael Iuvone

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