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Small molecules

Efficient Generation of Fully Reprogrammed Human iPS Cells via Polycistronic Retroviral Vector and a New Cocktail of Chemical Compounds

Zhonghui Zhang, Yongxing Gao, [ ... ], Wen-Shu Wu

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Dhara A. Patel, Anand C. Patel, [ ... ], Michael J. Holtzman

Novel Allosteric Sites on Ras for Lead Generation

Barry J. Grant, Suryani Lukman, [ ... ], Alemayehu A. Gorfe

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease

Daniel Todd, Ian Gowers, [ ... ], Jonathan A. Bard

Efficient and Rapid Induction of Human iPSCs/ESCs into Nephrogenic Intermediate Mesoderm Using Small Molecule-Based Differentiation Methods

Toshikazu Araoka, Shin-ichi Mae, [ ... ], Kenji Osafune

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

Fei Huang, Alexander V. Mazin

Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

Hung Yi Kristal Kaan, Adelene Y. L. Sim, [ ... ], Haiwei Song

Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences

Kirti Vaishnavi, Nishant Saxena, [ ... ], Renu Wadhwa

Differential Scanning Fluorometry Signatures as Indicators of Enzyme Inhibitor Mode of Action: Case Study of Glutathione S-Transferase

Wendy A. Lea, Anton Simeonov

Activation of Pluripotency Genes in Human Fibroblast Cells by a Novel mRNA Based Approach

Jordan R. Plews, JianLiang Li, [ ... ], Jie Na

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Thomas S. Peat, David I. Rhodes, [ ... ], John J. Deadman

Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

Matthias Steinfath, Silvia Vogl, [ ... ], Gilbert Schönfelder

Activation and Inhibition of Transglutaminase 2 in Mice

Laila Dafik, Megan Albertelli, [ ... ], Chaitan Khosla

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