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Small molecules

Direct Binding of a Hepatitis C Virus Inhibitor to the Viral Capsid Protein

Smitha Kota, Virginia Takahashi, Feng Ni, John K. Snyder, A. Donny Strosberg

published 28 Feb 2012

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Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

Bilal Çakir, Onur Dağliyan, Ezgi Dağyildiz, İbrahim Bariş, Ibrahim Halil Kavakli, Seda Kizilel, Metin Türkay

published 15 Feb 2012

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Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells

Joseph Kim, M. L. Richard Yip, Xiaoming Shen, Hubert Li, Li-Yu Charlie Hsin, Samuel Labarge, Eileen L. Heinrich, Wendy Lee, Jianming Lu, Nagarajan Vaidehi

published 03 Feb 2012

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Activation and Inhibition of Transglutaminase 2 in Mice

Laila Dafik, Megan Albertelli, Jorunn Stamnaes, Ludvig M. Sollid, Chaitan Khosla

published 02 Feb 2012

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An Immunoassay for Dibutyl Phthalate Based on Direct Hapten Linkage to the Polystyrene Surface of Microtiter Plates

Chenxi Wei, Shumao Ding, Huihui You, Yaran Zhang, Yao Wang, Xu Yang, Junlin Yuan

published 27 Dec 2011

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Novel Patient Cell-Based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease

Haifeng Geng, Grace Whiteley, Jameson Ribbens, Wei Zheng, Noel Southall, Xin Hu, Juan J. Marugan, Marc Ferrer, Gustavo H. B. Maegawa

published 21 Dec 2011

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Characterization of Pellicle Inhibition in Gluconacetobacter xylinus 53582 by a Small Molecule, Pellicin, Identified by a Chemical Genetics Screen

Janice L. Strap, Andrew Latos, Isaac Shim, Dario T. Bonetta

published 09 Dec 2011

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Discovery of Novel MDR-Mycobacterium tuberculosis Inhibitor by New FRIGATE Computational Screen

Christoph Scheich, Zoltán Szabadka, Beáta Vértessy, Vera Pütter, Vince Grolmusz, Markus Schade

published 02 Dec 2011

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Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

Sarosh N. Fatakia, Stefano Costanzi, Carson C. Chow

published 21 Nov 2011

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Efficient Generation of Fully Reprogrammed Human iPS Cells via Polycistronic Retroviral Vector and a New Cocktail of Chemical Compounds

Zhonghui Zhang, Yongxing Gao, Albert Gordon, Zack Z. Wang, Zhijian Qian, Wen-Shu Wu

published 26 Oct 2011

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Novel Allosteric Sites on Ras for Lead Generation

Barry J. Grant, Suryani Lukman, Harrison J. Hocker, Jaqueline Sayyah, Joan Heller Brown, J. Andrew McCammon, Alemayehu A. Gorfe

published 25 Oct 2011

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Xanthene Food Dye, as a Modulator of Alzheimer's Disease Amyloid-beta Peptide Aggregation and the Associated Impaired Neuronal Cell Function

H. Edward Wong, Inchan Kwon

published 05 Oct 2011

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Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity

Elizabeth R. Sharlow, Gabriela Mustata Wilson, David Close, Stephanie Leimgruber, Manuj Tandon, Robyn B. Reed, Tong Ying Shun, Q. Jane Wang, Peter Wipf, John S. Lazo

published 05 Oct 2011

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