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Small molecules

Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits In Vivo Bone Forming Activity

Seung-hwa Baek, Sik-Won Choi, [ ... ], Seong Hwan Kim

Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF

Anthony A. Emanuele, George A. Garcia

Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib

Mona M. Al-Shehri, Adel S. El-Azab, [ ... ], Ibrahim A. Darwish

Construction of an enantiopure bivalent nicotine vaccine using synthetic peptides

David F. Zeigler, Richard Roque, Christopher H. Clegg

Memory augmented recurrent neural networks for de-novo drug design

Naveen Suresh, Neelesh Chinnakonda Ashok Kumar, Srikumar Subramanian, Gowri Srinivasa

Effect of ENaC Modulators on Rat Neural Responses to NaCl

Shobha Mummalaneni, Jie Qian, [ ... ], Vijay Lyall

Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation

Saptarshi Kar, David W. Smith, Bruce S. Gardiner, Alan J. Grodzinsky

Highly multiplexed selection of RNA aptamers against a small molecule library

Brent Townshend, Matias Kaplan, Christina D. Smolke

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Camille Grandclément, Horst Pick, Horst Vogel, Werner Held

Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation

Yoshiko Mizukawa, Takaaki Doi, [ ... ], Tetsuo Shiohara

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

Richard L. Cullum, Lauren M. Lucas, [ ... ], David J. Riese, II

How important are concurrent vehicle control groups in (sub)chronic non-human primate toxicity studies conducted in pharmaceutical development? An opportunity to reduce animal numbers

Lars Mecklenburg, Sarah Lenz, Georg Hempel

Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction

Kelly M. Thayer, George A. Beyer

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