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Small molecules

Screen Anti-influenza Lead Compounds That Target the PA_C Subunit of H5N1 Viral RNA Polymerase

Lin Li, Shenghai Chang, [ ... ], Yingfang Liu

CD8+ T Cell Migration to the Skin Requires CD4+ Help in a Murine Model of Contact Hypersensitivity

Nanna Fyhrquist, Henrik Wolff, Antti Lauerma, Harri Alenius

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

Aaron Petty, Eugene Myshkin, [ ... ], Bingcheng Wang

Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule

Basappa , Kazuyuki Sugahara, [ ... ], Kanchugarakoppal S. Rangappa

Curcumin Prevents Formation of Polyglutamine Aggregates by Inhibiting Vps36, a Component of the ESCRT-II Complex

Meenakshi Verma, Abhishek Sharma, [ ... ], Vibha Taneja

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Bhuvanesh Dave, Melissa D. Landis, [ ... ], Jenny C. Chang

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions

Stefan Frank, Miao Zhang, Hans R. Schöler, Boris Greber

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti, Melissa A. Porter, [ ... ], William P. Janzen

DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells

Ada Ao, Jijun Hao, Corey R. Hopkins, Charles C. Hong

The Impact of Small Molecule Binding on the Energy Landscape of the Intrinsically Disordered Protein C-Myc

Julien Michel, Rémi Cuchillo

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Thomas S. Peat, David I. Rhodes, [ ... ], John J. Deadman

In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis

Jan Kazenwadel, Genevieve A. Secker, Kelly L. Betterman, Natasha L. Harvey

Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase

Sergey A. Shiryaev, Anton V. Cheltsov, Alex Y. Strongin

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