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Small molecules

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions

Stefan Frank, Miao Zhang, Hans R. Schöler, Boris Greber

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti, Melissa A. Porter, [ ... ], William P. Janzen

DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells

Ada Ao, Jijun Hao, Corey R. Hopkins, Charles C. Hong

The Impact of Small Molecule Binding on the Energy Landscape of the Intrinsically Disordered Protein C-Myc

Julien Michel, Rémi Cuchillo

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Thomas S. Peat, David I. Rhodes, [ ... ], John J. Deadman

In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis

Jan Kazenwadel, Genevieve A. Secker, Kelly L. Betterman, Natasha L. Harvey

Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase

Sergey A. Shiryaev, Anton V. Cheltsov, Alex Y. Strongin

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

Tatiana Ammosova, Maxim Platonov, [ ... ], Sergei Nekhai

Vital Dye Reaction and Granule Localization in Periplasm of Escherichia coli

Liyan Ping, Despoina A. I. Mavridou, [ ... ], Stuart J. Ferguson

On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53

Michal Bista, David Smithson, [ ... ], R. Kiplin Guy

Immunogenicity of a Promiscuous T Cell Epitope Peptide Based Conjugate Vaccine against Benzo[a]pyrene: Redirecting Antibodies to the Hapten

Mario T. Schellenberger, Nathalie Grova, [ ... ], Claude P. Muller

In Silico Assessment of Potential Druggable Pockets on the Surface of α₁-Antitrypsin Conformers

Anathe O. M. Patschull, Bibek Gooptu, [ ... ], Irene Nobeli

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Dhara A. Patel, Anand C. Patel, [ ... ], Michael J. Holtzman

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