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Small molecules

A Sensitive and Robust High-Throughput Screening Assay for Inhibitors of the Chikungunya Virus nsP1 Capping Enzyme

Kristen M. Bullard-Feibelman, Benjamin P. Fuller, Brian J. Geiss

Dynamics of Uptake and Metabolism of Small Molecules in Cellular Response Systems

Maria Werner, Szabolcs Semsey, Kim Sneppen, Sandeep Krishna

Halogenation Generates Effective Modulators of Amyloid-Beta Aggregation and Neurotoxicity

H. Edward Wong, Jacob A. Irwin, Inchan Kwon

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Katharina Schrade, Jessica Tröger, [ ... ], Enno Klussmann

Large-scale bioactivity analysis of the small-molecule assayed proteome

Tyler William H. Backman, Daniel S. Evans, Thomas Girke

Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

Silke Miller, Sara Rao, [ ... ], Narender R. Gavva

Screen Anti-influenza Lead Compounds That Target the PA_C Subunit of H5N1 Viral RNA Polymerase

Lin Li, Shenghai Chang, [ ... ], Yingfang Liu

The prognostic significance of DAPK1 in bladder cancer

Jian-Yun Xie, Peng-Chen Chen, [ ... ], Yao Lin

Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

Mariana P. Torrente, Laura M. Castellano, James Shorter

Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations

Frank Guarnieri, John L. Kulp Jr., John L. Kulp III, Ian S. Cloudsdale

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner, Darlene Romashko, [ ... ], Stuart Thomson

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

W. Joon Chung, Jennifer L. Goeckeler-Fried, [ ... ], Eric J. Sorscher

A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes

Chia-Chung Lee, Yang Lo, [ ... ], Hsu-Shan Huang

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