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Small molecules

A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization

Eliane V. Wolf, Annett Zeißler, [ ... ], Steven H. L. Verhelst

Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration

Yousef M. J. Al-Saraireh, Mark Sutherland, [ ... ], Robert A. Falconer

An In Silico Analysis of the Binding Modes and Binding Affinities of Small Molecule Modulators of PDZ-Peptide Interactions

Garima Tiwari, Debasisa Mohanty

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

Christina M. Buchanan, James M. J. Dickson, [ ... ], Peter R. Shepherd

A Simple and Fast Non-Radioactive Bridging Immunoassay for Insulin Autoantibodies

Ingrid Kikkas, Roberto Mallone, [ ... ], Nathalie Morel

Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

Karin Regnström, Jiangli Yan, [ ... ], Rick D. Artis

Towards Ligand Docking Including Explicit Interface Water Molecules

Gordon Lemmon, Jens Meiler

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II

Francesco Dituri, Antonio Mazzocca, [ ... ], Gianluigi Giannelli

Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor

Emma E. Vincent, Douglas J. E. Elder, [ ... ], Jeremy M. Tavaré

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Matthew D. Neal, Hongpeng Jia, [ ... ], David J. Hackam

Heat Shock Protein 90 Inhibitors Repress Latent Membrane Protein 1 (LMP1) Expression and Proliferation of Epstein-Barr Virus-Positive Natural Killer Cell Lymphoma

Takayuki Murata, Seiko Iwata, [ ... ], Tatsuya Tsurumi

Structural Basis of the Induced-Fit Mechanism of 1,4-Dihydroxy-2-Naphthoyl Coenzyme A Synthase from the Crotonase Fold Superfamily

Yueru Sun, Haigang Song, [ ... ], Zhihong Guo

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Peter Reinhardt, Michael Glatza, [ ... ], Jared Sterneckert

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