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Small molecules

Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

David C. Pryde, Lyn H. Jones, David P. Gervais, David R. Stead, David C. Blakemore, Matthew D. Selby, Alan D. Brown, Jotham W. Coe, Matthew Badland, David M. Beal, Rebecca Glen, Yvonne Wharton, Gavin J. Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R. Merson, Heather L. Davis, Michael J. McCluskie

published 01 Oct 2013

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Ligand Pose and Orientational Sampling in Molecular Docking

Ryan G. Coleman, Michael Carchia, Teague Sterling, John J. Irwin, Brian K. Shoichet

published 01 Oct 2013

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The Relationship between Functional Inhibition and Binding for K_Ca2 Channel Blockers

David Charles Hammond Benton, Monique Garbarg, Guy William John Moss

published 10 Sep 2013

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A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization

Eliane V. Wolf, Annett Zeißler, Oliver Vosyka, Evelyn Zeiler, Stephan Sieber, Steven H. L. Verhelst

published 22 Aug 2013

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Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration

Yousef M. J. Al-Saraireh, Mark Sutherland, Bradley R. Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M. Loadman, Rachel J. Errington, Paul J. Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H. Patterson, Steven D. Shnyder, Robert A. Falconer

published 09 Aug 2013

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An In Silico Analysis of the Binding Modes and Binding Affinities of Small Molecule Modulators of PDZ-Peptide Interactions

Garima Tiwari, Debasisa Mohanty

published 08 Aug 2013

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Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

Christina M. Buchanan, James M. J. Dickson, Woo-Jeong Lee, Mark A. Guthridge, Jackie D. Kendall, Peter R. Shepherd

published 01 Aug 2013

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A Simple and Fast Non-Radioactive Bridging Immunoassay for Insulin Autoantibodies

Ingrid Kikkas, Roberto Mallone, Nadia Tubiana-Rufi, Didier Chevenne, Jean Claude Carel, Christophe Créminon, Hervé Volland, Christian Boitard, Nathalie Morel

published 29 Jul 2013

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Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K. Hom, Brigit Riley, Don Rudolph, Michael F. Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P. Bova, Rick D. Artis

published 05 Jul 2013

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Towards Ligand Docking Including Explicit Interface Water Molecules

Gordon Lemmon, Jens Meiler

published 28 Jun 2013

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Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II

Francesco Dituri, Antonio Mazzocca, Fernando Juan Peidrò, Patrizia Papappicco, Isabel Fabregat, Flavia De Santis, Angelo Paradiso, Carlo Sabbà, Gianluigi Giannelli

published 27 Jun 2013

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Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor

Emma E. Vincent, Douglas J. E. Elder, Jon Curwen, Elaine Kilgour, Ingeborg Hers, Jeremy M. Tavaré

published 24 Jun 2013

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Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Matthew D. Neal, Hongpeng Jia, Benjamin Eyer, Misty Good, Christopher J. Guerriero, Chhinder P. Sodhi, Amin Afrazi, Thomas Prindle Jr, Congrong Ma, Maria Branca, John Ozolek, Jeffrey L. Brodsky, Peter Wipf, David J. Hackam

published 12 Jun 2013

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