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Small molecules

Identification of Small Molecule Activators of BMP Signaling

Karen Vrijens, Wenwei Lin, [ ... ], Martine F. Roussel

Biochemical Preparation of Cell Extract for Cell-Free Protein Synthesis without Physical Disruption

Kei Fujiwara, Nobuhide Doi

Progress towards a public chemogenomic set for protein kinases and a call for contributions

David H. Drewry, Carrow I. Wells, [ ... ], Timothy M. Willson

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

Nicholas J. Izzo, Agnes Staniszewski, [ ... ], Susan M. Catalano

A Systems Approach for Tumor Pharmacokinetics

Greg Michael Thurber, Ralph Weissleder

A Structure-Based Model for Predicting Serum Albumin Binding

Katrina W. Lexa, Elena Dolghih, Matthew P. Jacobson

Acute Drug Treatment in the Early C. elegans Embryo

Ana Carvalho, Sara K. Olson, [ ... ], Karen Oegema

Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

Aiysha Thompson, Jeffrey W. Stephens, Stephen C. Bain, Venkateswarlu Kanamarlapudi

In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections

Sarah Sze Wah Wong, Richard Yi Tsun Kao, [ ... ], Chaminda Jayampath Seneviratne

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

Nicholas J. Izzo, Jinbin Xu, [ ... ], Susan M. Catalano

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

Aaron Petty, Eugene Myshkin, [ ... ], Bingcheng Wang

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Gergely Tóth, Shyra J. Gardai, [ ... ], Lisa McConlogue

Efficient Generation of Fully Reprogrammed Human iPS Cells via Polycistronic Retroviral Vector and a New Cocktail of Chemical Compounds

Zhonghui Zhang, Yongxing Gao, [ ... ], Wen-Shu Wu

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