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Small molecules

Simultaneous Measurement of Smoothened Entry Into and Exit From the Primary Cilium

Jynho Kim, Elaine Y. C. Hsia, [ ... ], Xiaoyan Zheng

Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

Sharon Min Qi Chee, Jantana Wongsantichon, [ ... ], Farid J. Ghadessy

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Joseph Carver, Thomas S. Dexheimer, [ ... ], Ji Luo

Chemokine Receptor CXCR7 Is a Functional Receptor for CXCL12 in Brain Endothelial Cells

Yang Liu, Eleanor Carson-Walter, Kevin A. Walter

Imine Resveratrol Analogues: Molecular Design, Nrf2 Activation and SAR Analysis

Chang Li, Xiaofei Xu, Xiu Jun Wang, Yuanjiang Pan

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

Fei Huang, Alexander V. Mazin

Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever Mosquito Aedes aegypti

Matthew F. Rouhier, Rene Raphemot, Jerod S. Denton, Peter M. Piermarini

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable

Cindy Benod, Rosa Villagomez, [ ... ], Paul Webb

Investigating the Dynamic Aspects of Drug-Protein Recognition through a Combination of MD and NMR Analyses: Implications for the Development of Protein-Protein Interaction Inhibitors

Massimiliano Meli, Katiuscia Pagano, Laura Ragona, Giorgio Colombo

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

Inga Müller, Karin Larsson, [ ... ], Marie Arsenian Henriksson

Effect of ENaC Modulators on Rat Neural Responses to NaCl

Shobha Mummalaneni, Jie Qian, [ ... ], Vijay Lyall

A Novel TetR-Regulating Peptide Turns off rtTA-Mediated Activation of Gene Expression

Sebastian Schmidt, Christian Berens, Marcus Klotzsche

Effect of Currently Approved Carriers and Adjuvants on the Pre-Clinical Efficacy of a Conjugate Vaccine against Oxycodone in Mice and Rats

Marco Pravetoni, Jeffrey S. Vervacke, [ ... ], Paul R. Pentel

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