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Small molecules

Rational Design of Small-Molecule Stabilizers of Spermine Synthase Dimer by Virtual Screening and Free Energy-Based Approach

Zhe Zhang, Virginie Martiny, [ ... ], Maria A. Miteva

Non-Genetic Direct Reprogramming and Biomimetic Platforms in a Preliminary Study for Adipose-Derived Stem Cells into Corneal Endothelia-Like Cells

Ying Dai, Yonglong Guo, [ ... ], Jiansu Chen

Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

Mariana P. Torrente, Laura M. Castellano, James Shorter

Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines

Hosadurga K. Keerthy, Manoj Garg, [ ... ], H. Phillip Koeffler

Search for β₂ Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations

Qifeng Bai, Yonghua Shao, [ ... ], Xiaojun Yao

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Ganipisetti Srinivasrao, Jung-Eun Park, [ ... ], Jeong Kyu Bang

Improved Derivation Efficiency and Pluripotency of Stem Cells from the Refractory Inbred C57BL/6 Mouse Strain by Small Molecules

Chih-Jen Lin, Tomokazu Amano, Yong Tang, Xiuchun Tian

Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

Silke Miller, Sara Rao, [ ... ], Narender R. Gavva

Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

Graham M. West, Francis S. Willard, [ ... ], Patrick R. Griffin

KSR-Based Medium Improves the Generation of High-Quality Mouse iPS Cells

Kai Liu, Fang Wang, [ ... ], Lin Liu

Simultaneous Measurement of Smoothened Entry Into and Exit From the Primary Cilium

Jynho Kim, Elaine Y. C. Hsia, [ ... ], Xiaoyan Zheng

Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

Sharon Min Qi Chee, Jantana Wongsantichon, [ ... ], Farid J. Ghadessy

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Joseph Carver, Thomas S. Dexheimer, [ ... ], Ji Luo

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