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Small molecules

Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell Lines

Denise L. Driscoll, Arijit Chakravarty, Doug Bowman, Vaishali Shinde, Kerri Lasky, Judy Shi, Tricia Vos, Bradley Stringer, Ben Amidon, Natalie D'Amore, Marc L. Hyer

published 03 Nov 2014

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Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein

Reem R. Al Olaby, Laurence Cocquerel, Adam Zemla, Laure Saas, Jean Dubuisson, Jost Vielmetter, Joseph Marcotrigiano, Abdul Ghafoor Khan, Felipe Vences Catalan, Alexander L. Perryman, Joel S. Freundlich, Stefano Forli, Shoshana Levy, Rod Balhorn, Hassan M. Azzazy

published 30 Oct 2014

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Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide

Geqing Wang, Christopher A. MacRaild, Biswaranjan Mohanty, Mehdi Mobli, Nathan P. Cowieson, Robin F. Anders, Jamie S. Simpson, Sheena McGowan, Raymond S. Norton, Martin J. Scanlon

published 24 Oct 2014

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Rational Design of Small-Molecule Stabilizers of Spermine Synthase Dimer by Virtual Screening and Free Energy-Based Approach

Zhe Zhang, Virginie Martiny, David Lagorce, Yoshihiko Ikeguchi, Emil Alexov, Maria A. Miteva

published 23 Oct 2014

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Non-Genetic Direct Reprogramming and Biomimetic Platforms in a Preliminary Study for Adipose-Derived Stem Cells into Corneal Endothelia-Like Cells

Ying Dai, Yonglong Guo, Chan Wang, Qing Liu, Yan Yang, Shanyi Li, Xiaoling Guo, Ruiling Lian, Rongjie Yu, Hongwei Liu, Jiansu Chen

published 15 Oct 2014

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Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

Mariana P. Torrente, Laura M. Castellano, James Shorter

published 09 Oct 2014

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Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines

Hosadurga K. Keerthy, Manoj Garg, Chakrabhavi D. Mohan, Vikas Madan, Deepika Kanojia, Rangappa Shobith, Shivananju Nanjundaswamy, Daniel J. Mason, Andreas Bender, Basappa, Kanchugarakoppal S. Rangappa, H. Phillip Koeffler

published 30 Sep 2014

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Search for β₂ Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations

Qifeng Bai, Yonghua Shao, Dabo Pan, Yang Zhang, Huanxiang Liu, Xiaojun Yao

published 17 Sep 2014

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Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Ganipisetti Srinivasrao, Jung-Eun Park, Sungmin Kim, Mija Ahn, Chaejoon Cheong, Ky-Youb Nam, Pethaiah Gunasekaran, Eunha Hwang, Nam-Hyung Kim, Song Yub Shin, Kyung S. Lee, Eunkyung Ryu, Jeong Kyu Bang

published 11 Sep 2014

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Improved Derivation Efficiency and Pluripotency of Stem Cells from the Refractory Inbred C57BL/6 Mouse Strain by Small Molecules

Chih-Jen Lin, Tomokazu Amano, Yong Tang, Xiuchun Tian

published 11 Sep 2014

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Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

Silke Miller, Sara Rao, Weiya Wang, Hantao Liu, Judy Wang, Narender R. Gavva

published 09 Sep 2014

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Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

Graham M. West, Francis S. Willard, Kyle W. Sloop, Aaron D. Showalter, Bruce D. Pascal, Patrick R. Griffin

published 02 Sep 2014

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KSR-Based Medium Improves the Generation of High-Quality Mouse iPS Cells

Kai Liu, Fang Wang, Xiaoying Ye, Lingling Wang, Jiao Yang, Jingzhuo Zhang, Lin Liu

published 29 Aug 2014

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