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Small molecules

Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization

Valerie Berthelier, Jason Brett Harris, Kasey Noel Estenson, Jerome Baudry

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor

Carolin Lübker, Roland Seifert

Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells

Krzysztof Bryniarski, Wlodzimierz Ptak, [ ... ], Philip W. Askenase

Structure- and Ligand-Based Virtual Screening Identifies New Scaffolds for Inhibitors of the Oncoprotein MDM2

Douglas R. Houston, Li-Hsuan Yen, Simon Pettit, Malcolm D. Walkinshaw

Sequence, Structure and Ligand Binding Evolution of Rhodopsin-Like G Protein-Coupled Receptors: A Crystal Structure-Based Phylogenetic Analysis

Steffen Wolf, Stefan Grünewald

High Serum β-Lactams Specific/Total IgE Ratio Is Associated with Immediate Reactions to β-Lactams Antibiotics

Alessandra Vultaggio, Gianni Virgili, [ ... ], Andrea Matucci

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner, Darlene Romashko, [ ... ], Stuart Thomson

Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)

Julie A. Zorn, Qi Wang, [ ... ], John Kuriyan

Flavone Derivatives as Inhibitors of Insulin Amyloid-Like Fibril Formation

Ricardas Malisauskas, Akvile Botyriute, Jonathan G. Cannon, Vytautas Smirnovas

Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits In Vivo Bone Forming Activity

Seung-hwa Baek, Sik-Won Choi, [ ... ], Seong Hwan Kim

Tool Compounds Robustly Increase Turnover of an Artificial Substrate by Glucocerebrosidase in Human Brain Lysates

Zdenek Berger, Sarah Perkins, [ ... ], Warren D. Hirst

SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest

Manuj Tandon, Joseph M. Salamoun, [ ... ], Q. Jane Wang

Identification of Potential Small Molecule Allosteric Modulator Sites on IL-1R1 Ectodomain Using Accelerated Conformational Sampling Method

Chao-Yie Yang

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